Featured Research

from universities, journals, and other organizations

New Role In Asthma For Old Drug

Date:
February 5, 2007
Source:
Journal of Clinical Investigation
Summary:
The results of a study in mice by researchers from Erasmus University, The Netherlands, have indicated that an inhaled drug currently used to treat individuals with pulmonary arterial hypertension (raised blood pressure in the blood vessels in the lungs that leads to shortness of breath, dizziness, and fainting) might provide a new therapeutic to treat individuals with asthma.

The results of a study in mice by researchers from Erasmus University, The Netherlands, have indicated that an inhaled drug currently used to treat individuals with pulmonary arterial hypertension (raised blood pressure in the blood vessels in the lungs that leads to shortness of breath, dizziness, and fainting) might provide a new therapeutic to treat individuals with asthma.

Related Articles


Iloprost is a stable analog of the naturally occurring soluble factor PGI2. It is used to treat pulmonary arterial hypertension because it causes blood vessels to widen, thereby increasing blood flow and reducing blood pressure. However, recent studies have indicated that PGI2, and therefore iloprost, might also have anti-inflammatory properties.

In a study that appears in the February issue of the Journal of Clinical Investigation, Bart Lambrecht and colleagues show that inhalation of iloprost inhibits the Th2 cell inflammatory response that causes disease in a mouse model of allergic asthma. Inhalation of iloprost inhibited this response in two ways.

First, it prevented the immune cells in the lungs that activate the Th2 cell response (known as dendritic cells [DCs]) from leaving the lungs and going to the site at which they activate the allergic Th2 cell response. Second, it blocked the DCs becoming activated enough to stimulate an allergic Th2 cell response.

This study therefore indicates that targeting DCs in the lungs can suppress allergic asthma in mice and might lead to studies determining whether such targeting by iloprost can provide a new treatment for individuals with asthma.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "New Role In Asthma For Old Drug." ScienceDaily. ScienceDaily, 5 February 2007. <www.sciencedaily.com/releases/2007/02/070204111913.htm>.
Journal of Clinical Investigation. (2007, February 5). New Role In Asthma For Old Drug. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2007/02/070204111913.htm
Journal of Clinical Investigation. "New Role In Asthma For Old Drug." ScienceDaily. www.sciencedaily.com/releases/2007/02/070204111913.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins