Featured Research

from universities, journals, and other organizations

New Role In Asthma For Old Drug

Date:
February 5, 2007
Source:
Journal of Clinical Investigation
Summary:
The results of a study in mice by researchers from Erasmus University, The Netherlands, have indicated that an inhaled drug currently used to treat individuals with pulmonary arterial hypertension (raised blood pressure in the blood vessels in the lungs that leads to shortness of breath, dizziness, and fainting) might provide a new therapeutic to treat individuals with asthma.

The results of a study in mice by researchers from Erasmus University, The Netherlands, have indicated that an inhaled drug currently used to treat individuals with pulmonary arterial hypertension (raised blood pressure in the blood vessels in the lungs that leads to shortness of breath, dizziness, and fainting) might provide a new therapeutic to treat individuals with asthma.

Related Articles


Iloprost is a stable analog of the naturally occurring soluble factor PGI2. It is used to treat pulmonary arterial hypertension because it causes blood vessels to widen, thereby increasing blood flow and reducing blood pressure. However, recent studies have indicated that PGI2, and therefore iloprost, might also have anti-inflammatory properties.

In a study that appears in the February issue of the Journal of Clinical Investigation, Bart Lambrecht and colleagues show that inhalation of iloprost inhibits the Th2 cell inflammatory response that causes disease in a mouse model of allergic asthma. Inhalation of iloprost inhibited this response in two ways.

First, it prevented the immune cells in the lungs that activate the Th2 cell response (known as dendritic cells [DCs]) from leaving the lungs and going to the site at which they activate the allergic Th2 cell response. Second, it blocked the DCs becoming activated enough to stimulate an allergic Th2 cell response.

This study therefore indicates that targeting DCs in the lungs can suppress allergic asthma in mice and might lead to studies determining whether such targeting by iloprost can provide a new treatment for individuals with asthma.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "New Role In Asthma For Old Drug." ScienceDaily. ScienceDaily, 5 February 2007. <www.sciencedaily.com/releases/2007/02/070204111913.htm>.
Journal of Clinical Investigation. (2007, February 5). New Role In Asthma For Old Drug. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2007/02/070204111913.htm
Journal of Clinical Investigation. "New Role In Asthma For Old Drug." ScienceDaily. www.sciencedaily.com/releases/2007/02/070204111913.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins