Featured Research

from universities, journals, and other organizations

Combination Of Drugs Should Be Stockpiled To Fight Flu Pandemic, Say Experts

Date:
February 10, 2007
Source:
BMJ-British Medical Journal
Summary:
A combination of antiviral drugs should be stockpiled for use in an influenza pandemic, say researchers in this week's BMJ. We currently have two classes of drugs that are effective against influenza viruses: the ion channel inhibitors (amantadine and rimantadine) and the neuraminidase inhibitors (oseltamivir and zanamivir).

A combination of antiviral drugs should be stockpiled for use in an influenza pandemic, say researchers in this week's BMJ.

We currently have two classes of drugs that are effective against influenza viruses: the ion channel inhibitors (amantadine and rimantadine) and the neuraminidase inhibitors (oseltamivir and zanamivir).

Although ion channel inhibitors are effective against several strains of influenza viruses, they are not being widely stockpiled for a future flu pandemic because they cause unacceptable side effects and their use is associated with a rapid emergence of resistance.

But researchers argue that combining the two types of drugs may reduce side effects and the risk of resistance, and could play an important role in our armoury against a future flu pandemic.

In laboratory tests, the combination of ion channel and neuraminidase inhibitors reduced the emergence of resistance and even prevented the emergence of resistant strains of the highly pathogenic avian influenza H5N1 virus.

Ion channel inhibitors are also considerably cheaper than neuraminidase inhibitors, so the cost implications of maintaining stocks of both types of drug are therefore modest, say the authors. These drugs are also chemically stable, giving them a long shelf life.

The World Health Organisation recently recommended combined use of ion channel and neuraminidase inhibitors against the H5N1 strain, but this recommendation was deemed weak because of a lack of good evidence. Adequately sized trials of such combinations are therefore urgently needed, they add.

Several countries including the US, UK, and Greece are already stockpiling ion channel inhibitors. Other countries should consider following suit, say the authors. Failure to stockpile both types of antiviral drugs could prove costly.

An accompanying editorial discusses new guidelines on the clinical management of pandemic flu and says that the United Kingdom is well advanced in its preparations for a flu pandemic.


Story Source:

The above story is based on materials provided by BMJ-British Medical Journal. Note: Materials may be edited for content and length.


Cite This Page:

BMJ-British Medical Journal. "Combination Of Drugs Should Be Stockpiled To Fight Flu Pandemic, Say Experts." ScienceDaily. ScienceDaily, 10 February 2007. <www.sciencedaily.com/releases/2007/02/070209074203.htm>.
BMJ-British Medical Journal. (2007, February 10). Combination Of Drugs Should Be Stockpiled To Fight Flu Pandemic, Say Experts. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2007/02/070209074203.htm
BMJ-British Medical Journal. "Combination Of Drugs Should Be Stockpiled To Fight Flu Pandemic, Say Experts." ScienceDaily. www.sciencedaily.com/releases/2007/02/070209074203.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Quintuplets Head Home

Texas Quintuplets Head Home

Reuters - US Online Video (Aug. 1, 2014) After four months in the hospital, the first quintuplets to be born at Baylor University Medical Center head home. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Patient Coming to U.S. for Treatment

Ebola Patient Coming to U.S. for Treatment

Reuters - US Online Video (Aug. 1, 2014) A U.S. aid worker infected with Ebola while working in West Africa will be treated in a high security ward at Emory University in Atlanta. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins