Featured Research

from universities, journals, and other organizations

Researchers Show RNA Splicing Factor May Be New Target For Cancer Therapy

Date:
February 28, 2007
Source:
Cold Spring Harbor Laboratory
Summary:
New results in the field of RNA research establish that the RNA splicing factor SF2/ASF can act as a cancer-causing protein by changing the alternative splicing of other genes critical for growth-control of cells.

New results in the field of RNA research establish that the RNA splicing factor SF2/ASF can act as a cancer-causing protein by changing the alternative splicing of other genes critical for growth-control of cells. "Regulating the level of SF2/ASF in cells impacts tumor growth, making it a new potential target for cancer therapy," said Cold Spring Harbor Laboratory (CSHL) professor Adrian Krainer.

In humans and most other organisms, the RNA splicing process ensures proper protein production. Alternative splicing adds an important twist to this process that can change the precise course of protein production and lead to the generation of altered proteins with very different properties. In the worst case, these variant proteins can cause cancer.

Krainer's team found abnormally high levels of a particular splicing factor, SF2/ASF, in a variety of human cancers, particularly of the colon, lung, and breast. The research team was able to engineer non-cancerous mouse cells to produce this splicing factor in excess and found that these cells became cancerous. Conversely, when they reduced this protein in a cell line derived from a human lung tumor, the cells became non-cancerous.

The results identify many specific genes whose patterns of RNA splicing were altered when the splicing factor was produced in excess. Critical among these was a gene encoding a protein kinase that controls cell growth and protein synthesis. The Krainer team's research shows that a novel variant of this kinase, S6K1, can make cells cancerous and appears to be required to maintain some tumor cells in a cancerous state.


Story Source:

The above story is based on materials provided by Cold Spring Harbor Laboratory. Note: Materials may be edited for content and length.


Cite This Page:

Cold Spring Harbor Laboratory. "Researchers Show RNA Splicing Factor May Be New Target For Cancer Therapy." ScienceDaily. ScienceDaily, 28 February 2007. <www.sciencedaily.com/releases/2007/02/070218194431.htm>.
Cold Spring Harbor Laboratory. (2007, February 28). Researchers Show RNA Splicing Factor May Be New Target For Cancer Therapy. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2007/02/070218194431.htm
Cold Spring Harbor Laboratory. "Researchers Show RNA Splicing Factor May Be New Target For Cancer Therapy." ScienceDaily. www.sciencedaily.com/releases/2007/02/070218194431.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins