Featured Research

from universities, journals, and other organizations

Liposuctioned Fat Stem Cells To Repair Bodies

Date:
February 27, 2007
Source:
European Science Foundation
Summary:
Expanding waistlines, unsightly bulges: people will gladly remove excess body fat to improve their looks. But unwanted fat also contains stem cells with the potential to repair defects and heal injuries in the body. A team led by Philippe Collas at the University of Oslo in Norway has identified certain chemical marks that allow him to predict which, among the hundreds of millions of stem cells in liposuctioned fat, are best at regenerating tissue.

Expanding waistlines, unsightly bulges: people will gladly remove excess body fat to improve their looks. But unwanted fat also contains stem cells with the potential to repair defects and heal injuries in the body. A team led by Philippe Collas at the University of Oslo in Norway has identified certain chemical marks that allow him to predict which, among the hundreds of millions of stem cells in liposuctioned fat, are best at regenerating tissue.

Related Articles


Uncovering the nature and location of these molecular tags could allow scientists to pull off the ultimate trick of taking a patient’s own fat cells and using them for therapy, Collas told researchers gathered at the EuroSTELLS Workshop ‘Exploring Chromatin in Stem Cells’ held on January 23-24, in Montpellier, France.

“Fat tissue is an underappreciated source of stem cells,” Collas pointed out. Unlike other sources of adult stem cells, such as bone marrow, fat is abundant and there is no shortage of donors. “It’s wonderful, we have litres and litres of material from cosmetic surgery clinics and end up with bucketfuls of stem cells to work with,” he notes.

EuroSTELLS Project Leader Cesare Galli, from the University of Bologna, Italy has high hopes that transplanted fat stem cells will restore injured sports horses to their former glory. “Our aim is to regenerate the tendon structure that does not repair spontaneously,” says Galli. Once scar tissue is formed, it hinders the animal’s recovery.  “If you intervene, with cell transplants, within one week, you can repair the lesion,” Galli notes.

Like horses, humans are also vulnerable to joint injuries, and rehabilitations are long and costly. Now experience with horses is paving the way to cell therapies for sport-related tendon injuries in humans. Therapies using bone marrow stem cells, similar to fat stem cells, have achieved some successes, but the focus is shifting to fat, since the tissue is easier to access and extract than the bone marrow.

That fat-based methods work is not surprising, perhaps, because adipose tissue is closely related to bone, cartilage, muscle and other connective tissue. But some say it is impossible to re-programme adult cells to become nerve or liver cells, for example, without using embryos. Adult stem cells, such as those from fat, are thought to have more limited potential.

Collas insists that the transformation is possible. The hurdle lies not with the genes but with a cell’s epigenetic status, the subtle chemical modifications of DNA and its surrounding histone proteins. Epigenetic marks contribute to switching genes on and off, and stem cells rely on them heavily as they divide and mature. The Oslo team has found that low rates of DNA methylation, for instance, boost the chances of transforming fat stem cells from one cell type into another. “Look at a cell’s epigenetic profile,” says Collas, “and you may be able to predict what that cell is likely to turn into.”

These epigenetic signatures have grabbed everyone’s attention, acknowledges Ernest Arenas, a EuroSTELLS researcher at the Karolinska Institute in Stockholm, Sweden. “Scientists in the stem cell field are starting to realise that for cell manipulations to succeed they need to pay attention to their epigenetic marks. Cells can’t be pushed along to become a different cell type unless they start out with the right set of [epigenetic] conditions.”

It is a complex area but one that is loaded with promise. “Everyone is talking about epigenetics,” says Collas. If he has his way, people may soon be visiting plastic surgeons not just for cosmetic reasons, but for therapy. 

EuroSTELLS is the European Collaborative Research (EUROCORES) programme on “Development of a Stem Cell Tool Box” developed by the European Science Foundation.


Story Source:

The above story is based on materials provided by European Science Foundation. Note: Materials may be edited for content and length.


Cite This Page:

European Science Foundation. "Liposuctioned Fat Stem Cells To Repair Bodies." ScienceDaily. ScienceDaily, 27 February 2007. <www.sciencedaily.com/releases/2007/02/070222102406.htm>.
European Science Foundation. (2007, February 27). Liposuctioned Fat Stem Cells To Repair Bodies. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2007/02/070222102406.htm
European Science Foundation. "Liposuctioned Fat Stem Cells To Repair Bodies." ScienceDaily. www.sciencedaily.com/releases/2007/02/070222102406.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
WHO Says Male Ebola Survivors Should Abstain From Sex

WHO Says Male Ebola Survivors Should Abstain From Sex

Newsy (Nov. 28, 2014) — WHO cites four studies that say Ebola can still be detected in semen up to 82 days after the onset of symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins