Mar. 1, 2023 A major new study reveals a 'traffic light' mechanism controlling genetic activity within cells -- a system which could potentially be targeted by cancer drugs already in development. The ...
Jan. 12, 2023 More than 2,500 genes exhibit significant sex differences in expression in mouse alveolar type II cells (AT2s), important for keeping the lungs functioning, potentially explaining sex biases in the ...
Nov. 4, 2022 The gene-silencing complex HUSH might be involved in complex disorders affecting the brain and neurons. However, its mechanism of action remains unclear. Researchers now uncover the in vivo targets ...
Nov. 2, 2022 Toxicologists have found that the protein p53 continuously protects our cells from tumorigenesis by coordinating important metabolic processes that stabilize their ...
Oct. 4, 2022 Researchers describe how different types of repetitive DNA elements are controlled by the same silencing mechanism in fruit fly ovaries. Central to their findings is an uncharacterized protein that ...
Sep. 26, 2022 Changing the epigenetic marks on chromosomes leads to altered gene expression in offspring and in grandoffspring, demonstrating 'transgenerational epigenetic inheritance.' Without altering ...
Aug. 31, 2022 Changes known as epigenetic modifications play an important role in cancer development, among other things. Being able to analyze them quickly and reliably could, for example, contribute ...
Aug. 11, 2022 A fundamental discovery about a driver of healthy development in embryos could rewrite our understanding of what can be inherited from our parents and how their life experiences may shape ...
May 19, 2022 In most mammals, females have two X chromosomes and males have one X and one Y chromosome in each of their cells. To avoid a double dose of X-linked genes in females, one of the Xs is silenced early ...
May 4, 2022 Gene editing may be a potential treatment for anxiety and alcohol use disorder in adults who were exposed to binge drinking in their adolescence, according to the results of an animal study. The ...
Apr. 27, 2022 Researchers have discovered a gene responsible for prenatal death when critical epigenetic instructions are missing from egg cells. The study shows that in mice, failed epigenetic suppression of an ...
Apr. 18, 2022 Researchers have found that heterozygous loss of the methyl-CpG binding protein Zbtb38 downregulated the expression of the transcription factors Nanog and Sox2, as well as genes involved in epiblast ...
Apr. 5, 2022 Researchers have revealed how an 'accordion effect' is critical to switching off genes, in a study that transforms the fundamentals of what we know about gene silencing. The finding expands ...
Apr. 1, 2022 How is the activity of genes regulated by the packaging of DNA? To answer this question, researchers developed a technique to measure both gene expression and DNA packaging at the same ...
Mar. 10, 2022 Animals often use highly specific signals to warn their herd about approaching predators. Surprisingly, similar behaviors are also observed among plants. Shedding more light on this phenomenon, ...
Feb. 28, 2022 In humans and other eukaryotes, two principal epigenetic marks are known. A team has discovered a third, novel epigenetic mark -- one formerly known only in bacteria -- in bdelloid rotifers, small ...
Feb. 10, 2022 A new study has shown that the effects of pollutants can be transmitted over many generations in water fleas and may persist long enough to influence the evolutionary process. The research adds new ...
Feb. 8, 2022 Researchers discover a 'switch' specific to transcription factors that induce the genes essential for blood vessel development in postnatal periods. Mouse models further showed that the ...
Jan. 12, 2022 Hereditary diseases as well as cancers and cardiovascular diseases may be associated with a phenomenon known as genomic imprinting, in which only the maternally or paternally inherited gene is ...
Jan. 11, 2022 A team has shown that the CLASSY gene family regulates which parts of the genome are turned off in a tissue-specific manner. The work identifies the CLSY genes as major factors underlying epigenetic ...