Featured Research

from universities, journals, and other organizations

A New Target In The War On Cancer

Date:
February 26, 2007
Source:
American Chemical Society
Summary:
A new family of potential anti-cancer drugs is quietly causing excitement in the pharmaceutical industry as early data from clinical trials shows promising responses in patients, according to an article scheduled for the Feb. 26 issue of Chemical & Engineering News.

A new family of potential anti-cancer drugs is quietly causing excitement in the pharmaceutical industry as early data from clinical trials shows promising responses in patients, according to an article scheduled for the Feb. 26 issue of Chemical & Engineering News (C&EN), the ACS' weekly newsmagazine.

In the article, C&EN associate editor Lisa Jarvis explains that the new compounds may circumvent the long-standing problem of drug resistance, in which anti-cancer drugs gradually loose their effectiveness.

The drugs focus on a new target in the war against cancer — a substance called heat shock protein 90 (Hsp90). Heat shock proteins are most active when the cell is exposed to elevated temperatures, infection, inflammation, toxins and other stresses that can cause a protein to unfold. Like housekeepers, heat shock proteins help those proteins — including mutated, cancer-causing proteins — get back into their proper shape.

When Hsp90's effects are blocked in cancer cells, those cancer-causing proteins cannot survive, potentially stopping the disease in its track. When Hsp90's effects are blocked in cancer cells, damaged proteins accumulate, and the cell dies. Jarvis explains that cancer cells, with their horribly mutated proteins, seem to be especially dependent on Hsp90, and more vulnerable than other body cells when Hsp90's effects are blocked.

The article describes how new discoveries have changed heat shock proteins from laboratory curiosities into some of today's most promising targets for developing new drugs.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Cite This Page:

American Chemical Society. "A New Target In The War On Cancer." ScienceDaily. ScienceDaily, 26 February 2007. <www.sciencedaily.com/releases/2007/02/070226095825.htm>.
American Chemical Society. (2007, February 26). A New Target In The War On Cancer. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2007/02/070226095825.htm
American Chemical Society. "A New Target In The War On Cancer." ScienceDaily. www.sciencedaily.com/releases/2007/02/070226095825.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com
What's To Blame For Worst Ebola Outbreak In History?

What's To Blame For Worst Ebola Outbreak In History?

Newsy (July 27, 2014) A U.S. doctor has tested positive for the deadly Ebola virus, as the worst-ever outbreak continues to grow. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins