Featured Research

from universities, journals, and other organizations

Comparison Of Immune Response To 1918 And H5N1 Influeza Viruses Shows Similarities

Date:
March 2, 2007
Source:
American Society for Microbiology
Summary:
A comparison of the 1918 Spanish influenza and the H5N1 avian influenza viruses suggests that while the two viruses appear to trigger a similar abnormal immune response in animal models, there are distinct differences. Researchers from the University of Washington School of Medicine in Seattle report their findings today at the ASM Biodefense and Emerging Disease Research Meeting.

A comparison of the 1918 Spanish influenza and the H5N1 avian influenza viruses suggests that while the two viruses appear to trigger a similar abnormal immune response in animal models, there are distinct differences. Researchers from the University of Washington School of Medicine in Seattle reported their findings at the ASM Biodefense and Emerging Disease Research Meeting.

Related Articles


"The influenza pandemic of 1918-19 was responsible for at least 40 million deaths worldwide. Recent experiments in mouse and nonhuman primates have suggested a central role of the host immune response in 1918 and H5N1 disease severity," says John Kash, a lead researcher on the study.

Kash and his colleagues have previously published research on how the immune system responds to infection with the 1918 virus in mouse and nonhuman primate lungs, using bioinformatic tools to see what genes within the immune system are expressed in response to infection. They discovered that the virus caused an almost immediate and overwhelming immune system response that basically turned the immune systems of its victims against them.

In the current study, Kash and colleagues examined the gene expression in response to H5N1 avain influenza virus in mouse lungs and compared the immune response to the previously collected data on the 1918 influenza virus.

"It looks like both these viruses elicit some sort of overblown inflammatory response. While at a fundamental level they look very similar to each other, there are subtle distinctions," says Kash.

In studying these commonalities and differences, Kash hopes to better understand how the viruses cause disease and hopefully develop new treatments. Eventually scientists may be able to develop drugs that could turn down or even switch off the unwanted activity while still allowing the immune system to combat the infection.

"What we are trying to do is understand the similarities and differences and what they mean. If we can understand those common mechanisms, we can better develop new treatments for the disease," says Kash.

The American Society for Microbiology (ASM) is the largest single life science society, composed of over 42,000 scientists, teachers, physicians, and health professionals. Its mission is to promote research and training in the microbiological sciences and to assist communication between scientists, policymakers, and the public to improve health, economic well-being, and the environment.

Further information on the ASM Biodefense and Emerging Disease Research Meeting can be found online at http://www.asmbiodefense.org.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Microbiology. "Comparison Of Immune Response To 1918 And H5N1 Influeza Viruses Shows Similarities." ScienceDaily. ScienceDaily, 2 March 2007. <www.sciencedaily.com/releases/2007/03/070301082002.htm>.
American Society for Microbiology. (2007, March 2). Comparison Of Immune Response To 1918 And H5N1 Influeza Viruses Shows Similarities. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2007/03/070301082002.htm
American Society for Microbiology. "Comparison Of Immune Response To 1918 And H5N1 Influeza Viruses Shows Similarities." ScienceDaily. www.sciencedaily.com/releases/2007/03/070301082002.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins