Featured Research

from universities, journals, and other organizations

Gene Tests And Brain Imaging Reveal Early Dementia

Date:
March 9, 2007
Source:
Karolinska Institutet
Summary:
Dementia diseases develop insidiously and are generally discovered when the memory has already started to deteriorate. New research form Swedish medical university Karolinska Institutet shows, however, that approaching Alzheimer's can be detected several years before the symptoms manifest themselves.

Alzheimer´s disease (AD) is the most common form of dementia. An important goal for current AD research is to find preclinical markers of impending disease. Apolipoprotein E sigma4 (APOE epsilon4) is the chief known genetic risk factor for AD.

Related Articles


A number of neuroimaging studies have reported structural and functional brain alterations in non-demented APOE epsilon4-carriers. Such results have tentatively been interpreted as early signs of impending dementia, but the findings have been inconsistent across studies. To further address this issue, the overall aim of this thesis was to examine asymptomatic cognitively well-functioning APOE epsilon4-carriers with magnetic resonance imaging (MRI) techniques, together with longitudinal neuropsychological testing.

Study I revealed that carriers of APOE epsilon4 expressed reduced functional brain activity during incidental episodic encoding. In the parietal cortex, a genetic dose-effect was seen such that the activity reduction was more pronounced for homozygous than heterozygous APOE epsilon4-carriers. In addition, it was found that APOE epsilon4-carriers had structural changes in white-matter tracts in the hippocampus and the posterior corpus callosum (Study II), and grey matter reductions in the hippocampus (Study III). Study IV demonstrated that the degree of functional activity in the parietal cortex predicted subsequent episodic memory decline within the group of APOE epsilon4-carriers.

Collectively, the results suggest that a combination of genetic, neuropsychological, and neuroimaging strategies is beneficial in predicting AD development.


Story Source:

The above story is based on materials provided by Karolinska Institutet. Note: Materials may be edited for content and length.


Cite This Page:

Karolinska Institutet. "Gene Tests And Brain Imaging Reveal Early Dementia." ScienceDaily. ScienceDaily, 9 March 2007. <www.sciencedaily.com/releases/2007/03/070306101116.htm>.
Karolinska Institutet. (2007, March 9). Gene Tests And Brain Imaging Reveal Early Dementia. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2007/03/070306101116.htm
Karolinska Institutet. "Gene Tests And Brain Imaging Reveal Early Dementia." ScienceDaily. www.sciencedaily.com/releases/2007/03/070306101116.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
Toxin-Packed Stem Cells Used To Kill Cancer

Toxin-Packed Stem Cells Used To Kill Cancer

Newsy (Oct. 25, 2014) — A Harvard University Research Team created genetically engineered stem cells that are able to kill cancer cells, while leaving other cells unharmed. Video provided by Newsy
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins