Featured Research

from universities, journals, and other organizations

Lung Cancer Risk Reduced In Female Textile Workers Exposed To Endotoxin

Date:
March 7, 2007
Source:
Journal of the National Cancer Institute
Summary:
Long-term, high-level exposure to bacterial endotoxin -- a contaminant found in raw cotton fiber and cotton dust -- is associated with a 40 percent decrease in lung cancer risk among female Chinese textile workers, according to a new study in the March 7 Journal of the National Cancer Institute.

Long-term, high-level exposure to bacterial endotoxin-- a contaminant found in raw cotton fiber and cotton dust -- is associated with a 40 percent decrease in lung cancer risk among female Chinese textile workers, according to a new study in the March 7 Journal of the National Cancer Institute.

Related Articles


Since the 1970s, studies in the U.S. and abroad have reported a lower than average risk of lung cancer for textile workers. Additionally, studies have shown that workers in other occupations with high endotoxin exposure, such as dairy farmers, have reduced lung cancer risks as well. Although many researchers thought endotoxin might be associated with reduced risk of lung cancer, no previous studies had quantified the relationship between endotoxin exposure and lung cancer risk.

George Astrakianakis, Ph.D., of the University of Washington in Seattle, and his colleagues compared the endotoxin exposure of 628 female cotton textile workers in Shanghai who were diagnosed with lung cancer with a group of 3,184 female workers without lung cancer who were matched by age to the cancer patients. They estimated the workers' total endotoxin exposure in textile factories based on their measurements of cotton dust exposure, which varied depending on the workers' jobs and length of employment.

The risk of developing lung cancer decreased as workers were exposed to greater amounts of endotoxin over many years. Twenty years of exposure to endotoxin reduced the incidence of lung cancer to approximately 7.6 per 100,000, compared with 19.1 per 100,000 for the average Shanghai woman. The risk was lowest for women whose endotoxin exposure occurred early in their career.

How endotoxins could reduced lung cancer risk is unclear. "Potential anticarcinogenic effects of endotoxin are probably mediated by the innate and acquired immune systems, although the specific mechanisms have yet to be elucidated," the authors write.

The researchers considered several other factors that could have influenced their results. The protective effect of endotoxin could not be explained by differences in smoking habits, but the authors could not exclude a potential bias in the study's design, which they call the healthy worker survivor effect. The authors also acknowledge that uncertainties exist in estimating endotoxin exposures in past years, but the findings remained virtually unchanged when different exposure scenarios were applied.

In an accompanying editorial, Paolo Boffetta, M.D., of the International Agency for Research on Cancer in France, discusses the importance of this finding for lung cancer research, but warns that the study's limitations make it too early to consider using endotoxins for lung cancer prevention. "Results of the study by Astrakianakis [and colleagues] are strongly suggestive that endotoxin exposure is associated with a reduced risk of lung cancer, but potential confounding [variables] and lack of strong supportive mechanistic evidence prevent stronger conclusions," Boffetta writes. "Great caution should be exercised by all when moving from the results of observational studies of the effects of complex mixtures to interventions aimed at cancer prevention."

Article: Astrakianakis G, Seixas NS, Ray R, Camp JE, Gao DL, Feng Z, et al. Lung Cancer Risk Among Female Textile Workers Exposed to Endotoxin. J Natl Cancer Inst 2007; 99: 357-364

Editorial: Boffetta P. Endotoxins in Lung Cancer Prevention. J Natl Cancer Inst 2007 99: 339

Note: The Journal of the National Cancer Institute is published by Oxford University Press and is not affiliated with the National Cancer Institute. Attribution to the Journal of the National Cancer Institute is requested in all news coverage. Visit the Journal online at http://jnci.oxfordjournals.org/.


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal of the National Cancer Institute. "Lung Cancer Risk Reduced In Female Textile Workers Exposed To Endotoxin." ScienceDaily. ScienceDaily, 7 March 2007. <www.sciencedaily.com/releases/2007/03/070307075802.htm>.
Journal of the National Cancer Institute. (2007, March 7). Lung Cancer Risk Reduced In Female Textile Workers Exposed To Endotoxin. ScienceDaily. Retrieved November 22, 2014 from www.sciencedaily.com/releases/2007/03/070307075802.htm
Journal of the National Cancer Institute. "Lung Cancer Risk Reduced In Female Textile Workers Exposed To Endotoxin." ScienceDaily. www.sciencedaily.com/releases/2007/03/070307075802.htm (accessed November 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, November 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Raw: Paralyzed Marine Walks With Robotic Braces

Raw: Paralyzed Marine Walks With Robotic Braces

AP (Nov. 21, 2014) Marine Corps officials say a special operations officer left paralyzed by a sniper's bullet in Afghanistan walked using robotic leg braces in a ceremony to award him a Bronze Star. (Nov. 21) Video provided by AP
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins