Featured Research

from universities, journals, and other organizations

Study Identifies Steps To Improve Safety Of Renal Artery Stenting

Date:
April 3, 2007
Source:
American College of Cardiology
Summary:
High blood pressure is the most common chronic medical condition in the U.S., and the most common identifiable cause is renal artery stenosis. Renal artery stenting is a widely performed but controversial procedure for patients. Use of a platelet inhibitor may make renal artery stenting safer for patients, especially when used in combination with an embolic protection device, according to a study presented today at the American College of Cardiology's Innovation in Intervention: i2 Summit.

High blood pressure is the most common chronic medical condition in the United States, and the most common identifiable cause is narrowing of a kidney artery, called renal artery stenosis. Renal artery stenting is a widely performed but controversial procedure for patients with narrowed kidney arteries. Studies have demonstrated little improvement in average kidney function with a significant minority of patients experiencing a decline in kidney function after the procedure.

Use of a platelet inhibitor may make renal artery stenting safer for patients, especially when used in combination with an embolic protection device (EPD), according to a study presented at the American College of Cardiology's Innovation in Intervention: i2 Summit in New Orleans, La. EPDs are filters that safely trap and remove much of the debris that may be dislodged during interventional procedures.

Renal artery stenosis not only leads to high blood pressure, or hypertension, but can also lead to chronic failure of the kidney. This is the first study to test whether using glycoprotein IIb/IIIa inhibitors and EPDs would improve renal function following the stenting. To test the value of the combination therapy regimen, a total of 100 patients undergoing renal artery stenting at seven centers were randomized to EPD(Angioguard™) or double-blinded use of a glycoprotein IIb/IIIa inhibitor (abciximab) in a 2x2 factorial design. Patients' key functions were recorded, including kidney function, activation of platelets and the presence of platelet-rich thrombus (blood clots) in the filter baskets of the EPDs. The main effects of treatments and their interaction were assessed by percent change in MDRD-derived GFR from baseline to one month. MDRD-derived GFR (glomerular filtration rate) is a widely accepted estimated measure of kidney function, usually based on serum creatinine level, age, sex and race.

Researchers found that an overall improvement in renal function was only observed in patients allocated to both treatments. Abciximab reduced the occurrence of platelet-rich emboli (particles or debris) in the EPD from 42 to seven percent. This difference was highly significant compared to the three other possible allocations in the 2x2 design. EPD alone was not associated with improved renal function, whereas the use of a glycoprotein IIb/IIIa inhibitor showed measurable benefit.

"When examined independently, the platelet inhibitor abciximab appeared to have beneficial effects, but Angioguard did not appear to be noticeably helpful," said Christopher J. Cooper, M.D., of the University of Toledo and lead author of the study. "However, the group treated with both Angioguard and abciximab in combination benefited the most from treatment, illustrating a significant interaction effect. Like many other studies, we are finding that patients benefit from a combination of therapeutic strategies; in this case, the filter and the drug serve patients best when doctors use both in combination."

Dr. Cooper will present the results of the "Embolic Protection and Platelet Inhibition During Renal Artery Stenting" study at the American College of Cardiology's Innovation in Intervention: i2 Summit in New Orleans, La.


Story Source:

The above story is based on materials provided by American College of Cardiology. Note: Materials may be edited for content and length.


Cite This Page:

American College of Cardiology. "Study Identifies Steps To Improve Safety Of Renal Artery Stenting." ScienceDaily. ScienceDaily, 3 April 2007. <www.sciencedaily.com/releases/2007/03/070326120939.htm>.
American College of Cardiology. (2007, April 3). Study Identifies Steps To Improve Safety Of Renal Artery Stenting. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2007/03/070326120939.htm
American College of Cardiology. "Study Identifies Steps To Improve Safety Of Renal Artery Stenting." ScienceDaily. www.sciencedaily.com/releases/2007/03/070326120939.htm (accessed April 16, 2014).

Share This



More Health & Medicine News

Wednesday, April 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com
Cognitive Function: Is It All Downhill From Age 24?

Cognitive Function: Is It All Downhill From Age 24?

Newsy (Apr. 15, 2014) A new study out of Canada says cognitive motor performance begins deteriorating around age 24. Video provided by Newsy
Powered by NewsLook.com
How Mt. Everest Helped Scientists Research Diabetes

How Mt. Everest Helped Scientists Research Diabetes

Newsy (Apr. 15, 2014) British researchers were able to use Mount Everest's low altitudes to study insulin resistance. They hope to find ways to treat diabetes. Video provided by Newsy
Powered by NewsLook.com
Carpenter's Injury Leads To Hundreds Of 3-D-Printed Hands

Carpenter's Injury Leads To Hundreds Of 3-D-Printed Hands

Newsy (Apr. 14, 2014) Richard van As lost all fingers on his right hand in a woodworking accident. Now, he's used the incident to create a prosthetic to help hundreds. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins