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Parkinson's Disease: Nicotine Could Help; Pesticides Harm

Date:
April 5, 2007
Source:
The Parkinson's Institute
Summary:
The Parkinson's Institute announced new findings concerning the role of environmental factors in the development of Parkinson's disease.

The Parkinson's Institute recently announced new findings concerning the role of environmental factors in the development of Parkinson's disease.

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Highlights of the research include:

  • The role of pesticides (eg. Paraquat and Dieldrin) as potential risk factors for Parkinson's disease, a role suggested by both epidemiological statistics and laboratory evidence.
  • The threat of toxic agents to damage neurons by causing the accumulation of harmful proteins.
  • Intraneuronal protein aggregates as markers of Parkinson's pathology, based on work carried out at The Parkinson's Institute indicating that these aggregates could be formed as a consequence of toxic exposure.
  • The importance of targeting a specific protein, alpha-synuclein, in order to achieve neuroprotection in Parkinson's
  • The role of inflammation in the development of Parkinson's disease and the possibility that anti-inflammatory drugs could be beneficial to patients.
  • The possibility that nicotine may act as a neuroprotective agent.

These results will be reported at Asilomar (Pacific Grove, CA) as part of the final meeting of the Collaborative Centers for Parkinson's Disease Environmental Research (CCPDER). This collaborative research effort, sponsored by the National Institute of Environmental Health Sciences (NIEHS), brings together investigators from Emory University, the University of California Los Angeles and The Parkinson's Institute, which has served as the coordinating center for the study.

"Our collaboration with Emory University and UCLA has allowed us to make great strives in identifying environmental factors involved in the development of Parkinson's disease," said Donato A. Di Monte, M.D., director of basic research at The Parkinson's Institute. "The findings that will be discussed at Asilomar will help us better understand the disease process, intervene earlier with neuroprotective treatment and work on preventive measures against Parkinson's disease risk factors."


Story Source:

The above story is based on materials provided by The Parkinson's Institute. Note: Materials may be edited for content and length.


Cite This Page:

The Parkinson's Institute. "Parkinson's Disease: Nicotine Could Help; Pesticides Harm." ScienceDaily. ScienceDaily, 5 April 2007. <www.sciencedaily.com/releases/2007/04/070405094050.htm>.
The Parkinson's Institute. (2007, April 5). Parkinson's Disease: Nicotine Could Help; Pesticides Harm. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2007/04/070405094050.htm
The Parkinson's Institute. "Parkinson's Disease: Nicotine Could Help; Pesticides Harm." ScienceDaily. www.sciencedaily.com/releases/2007/04/070405094050.htm (accessed October 31, 2014).

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