Featured Research

from universities, journals, and other organizations

Minimally Invasive Lung Cancer Surgery Can Improve Chemotherapy Outcomes

Date:
April 10, 2007
Source:
Duke University Medical Center
Summary:
Patients who undergo a minimally invasive lung cancer surgery called thoracoscopic lobectomy may derive more benefit from the chemotherapy that follows, according to Duke University Medical Center researchers. These patients also have shorter hospital stays and accelerated recovery time compared with patients who have their tumors removed using the traditional surgical approach that involves opening the chest.

Patients who undergo a minimally invasive lung cancer surgery called thoracoscopic lobectomy may derive more benefit from the chemotherapy that follows, according to Duke University Medical Center researchers. These patients also have shorter hospital stays and accelerated recovery time compared with patients who have their tumors removed using the traditional surgical approach that involves opening the chest.

"This study showed that patients who had the minimally invasive operation were less likely to experience delays in receiving chemotherapy or a reduction in the amount of chemotherapy we were able to give," said Thomas D'Amico, M.D., a lung surgeon and senior investigator on the study. "Chemotherapy after surgery has been shown to improve survival in lung cancer patients, so the more effectively we deliver that chemotherapy, the better."

Thoracoscopic lobectomy is performed through two or three small incisions in the side of the chest. Surgeons insert a camera through one of the incisions and view the inside of the chest on a video screen, while manipulating instruments through the other incisions to remove the tumors. Open surgery to remove lung tumors -- called thoracotomy -- requires surgeons to make larger incisions and spread or cut the ribs in order to access the patient's lungs.

Doctors have been using thoracoscopic lobectomy as a surgical alternative for approximately 15 years; it can be an option for patients with non-small cell lung cancer, which is the most common type of lung cancer, making up 85 percent of all cases. The technique is most successful in patients whose tumors are less than six centimeters in size, D'Amico said.

Currently in the United States, only about 10 percent of lung cancer surgeries are performed thoracoscopically, but more than half of all patients requiring surgery to remove lung cancer might be candidates for the minimally invasive procedure, D'Amico said.

"The impetus for this study involved a speculation that if chemotherapy in addition to surgery improves outcomes, patients would benefit even more if chemotherapy were delivered in the most effective manner possible," said Rebecca Petersen, M.D., a general surgery resident at Duke and lead investigator on the study. "We found that thoracoscopy improves the ability to effectively deliver chemotherapy, which is yet another advantage of this minimally invasive technique."

Patients, especially those who have the traditional open surgery, often lose out on some of chemotherapy's benefits because their treatment is delayed or cut short due to surgery-related complications, such as bleeding or excessive inflammation, that could impair their immune systems, D'Amico said. The time it takes to recover from surgery could also reduce the efficacy of chemotherapy, and patients having a minimally invasive surgery recover faster, he said.

"This study showed that patients who had their tumors removed thoracoscopically were less likely to experience interruptions or delays in their chemotherapy delivery plan," he said.

Researchers looked at the outcomes, including delays or reductions in chemotherapy delivery, for 100 patients treated at Duke with either minimally invasive thoracoscopic surgery or traditional surgery. Eighteen percent of the patients who had the minimally invasive surgery experienced delayed chemotherapy, compared with 58 percent of the patients who had the traditional surgery, D'Amico said.

Only 26 percent of the thoracoscopic group experienced a reduction in the dosage of their planned chemotherapy regimen, compared to 49 percent of patients who underwent the open-chest surgery, he said.

The researchers published the findings in the April 2007 issue of the Annals of Thoracic Surgery. The study was funded by Duke's Department of Surgery. Other researchers in the study were DuyKhanh Pham, William Burfeind, Steven Hanish, Eric Toloza and David Harpole.


Story Source:

The above story is based on materials provided by Duke University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Duke University Medical Center. "Minimally Invasive Lung Cancer Surgery Can Improve Chemotherapy Outcomes." ScienceDaily. ScienceDaily, 10 April 2007. <www.sciencedaily.com/releases/2007/04/070409144740.htm>.
Duke University Medical Center. (2007, April 10). Minimally Invasive Lung Cancer Surgery Can Improve Chemotherapy Outcomes. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2007/04/070409144740.htm
Duke University Medical Center. "Minimally Invasive Lung Cancer Surgery Can Improve Chemotherapy Outcomes." ScienceDaily. www.sciencedaily.com/releases/2007/04/070409144740.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins