Featured Research

from universities, journals, and other organizations

Epilepsy Drug With New Method Of Action Is Safe, Effective, Study Shows

Date:
April 11, 2007
Source:
American Academy of Neurology
Summary:
A drug for epilepsy with a new mechanism of action is safe and effective, according to a study published in Neurology.

A drug for epilepsy with a new mechanism of action is safe and effective, according to a study published in the April 10, 2007, issue of Neurology®, the scientific journal of the American Academy of Neurology.

Related Articles


"This is good news for the many people with epilepsy who do not respond well to the current available medications," said study author Roger J. Porter, MD, of the University of Pennsylvania in Philadelphia and Fellow of the American Academy of Neurology, who was an employee of Wyeth Pharmaceuticals at the time the study was performed.

The drug retigabine acts by opening potassium channels. The drug is used in people with partial-onset seizures whose seizures are not fully controlled by other drugs. For the study, researchers divided 399 people into four groups. One group received a placebo and the other three groups received different doses of retigabine for 16 weeks. All of the participants were having an average of eight to 10 seizures a month and were also taking one to two other drugs for epilepsy.

Those taking the highest dose of the drug had an average of 35 percent fewer seizures during the study, compared to 13 percent fewer for those taking the placebo. And 33 percent of those taking the highest dosage of the drug had a 50-percent or greater reduction in their seizure frequency.

Side effects included drowsiness, dizziness, confusion, tremor, amnesia, and speech disorders. A total of 79 people withdrew from the study, including 12 people who were receiving the placebo. Porter said the dropout rate when compared with placebo is similar to that seen with other anti-epileptic drugs and is generally due to study design where people are often asked to take high doses in order to maximize benefit.

"Doctors had to increase the patients' dosages on a set schedule for the study," he said. "In regular practice, doctors can decrease the dose, at least temporarily, when a patient has side effects, but that was not possible in this study. Some of the participants might have better tolerated a more flexible dosing schedule."

The study was sponsored and conducted by Wyeth Pharmaceuticals, which developed retigabine. Valeant Pharmaceuticals is the current owner of retigabine and the drug is currently in the late stages of development as an added therapy for partial-onset seizures in adults.


Story Source:

The above story is based on materials provided by American Academy of Neurology. Note: Materials may be edited for content and length.


Cite This Page:

American Academy of Neurology. "Epilepsy Drug With New Method Of Action Is Safe, Effective, Study Shows." ScienceDaily. ScienceDaily, 11 April 2007. <www.sciencedaily.com/releases/2007/04/070409164949.htm>.
American Academy of Neurology. (2007, April 11). Epilepsy Drug With New Method Of Action Is Safe, Effective, Study Shows. ScienceDaily. Retrieved January 30, 2015 from www.sciencedaily.com/releases/2007/04/070409164949.htm
American Academy of Neurology. "Epilepsy Drug With New Method Of Action Is Safe, Effective, Study Shows." ScienceDaily. www.sciencedaily.com/releases/2007/04/070409164949.htm (accessed January 30, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Friday, January 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Binge-Watching TV Linked To Loneliness

Binge-Watching TV Linked To Loneliness

Newsy (Jan. 29, 2015) — Researchers at University of Texas at Austin found a link between binge-watching TV shows and feelings of loneliness and depression. Video provided by Newsy
Powered by NewsLook.com
Signs You Might Be The Passive Aggressive Friend

Signs You Might Be The Passive Aggressive Friend

BuzzFeed (Jan. 28, 2015) — "No, I&apos;m not mad. Why, are you mad?" Video provided by BuzzFeed
Powered by NewsLook.com
City Divided: A Look at Model Schools in the TDSB

City Divided: A Look at Model Schools in the TDSB

The Toronto Star (Jan. 27, 2015) — Model schools are rethinking how they engage with the community to help enhance the lives of the students and their parents. Video provided by The Toronto Star
Powered by NewsLook.com
Man Saves Pennies For 65 Years

Man Saves Pennies For 65 Years

Rooftop Comedy (Jan. 26, 2015) — A man in Texas saved every penny he found for 65 years, and this week he finally cashed them in. Bank tellers at Prosperity Bank in Slaton, Texas were shocked when Ira Keys arrived at their bank with over 500 pounds of loose pennies stored in coffee cans. After more than an hour of sorting and counting, it turned out the 81 year-old was in possession of 81,600 pennies, or $816. And he&apos;s got more at home! Video provided by Rooftop Comedy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins