Featured Research

from universities, journals, and other organizations

Childhood Sarcoma Increases Risk Of Blood Clots, Researchers Find

Date:
April 19, 2007
Source:
NIH/National Cancer Institute
Summary:
Researchers at the National Cancer Institute have determined that children and young adults with a form of cancer called sarcoma are at increased risk of having a thromboembolic event in their veins. Thromboembolic events can be a blood clot in a vessel that can interfere with normal blood flow. Investigating the association between sarcoma and TE is important because the majority of children with sarcoma can be cured of their cancer, but the occurrence of TEs could adversely compromise this success.

Researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, have determined that children and young adults with a form of cancer called sarcoma are at increased risk of having a thromboembolic event (TE) in their veins. Thromboembolic events can be a blood clot in a vessel that can interfere with normal blood flow. Clots can sometimes break loose and travel through the blood stream to form new clots at locations in the body that are life-threatening. TEs are almost always treatable if detected early. Investigating the association between sarcoma and TE is important because the majority of children with sarcoma can be cured of their cancer, but the occurrence of TEs could adversely compromise this success.

Related Articles


The study investigators also found that pediatric patients whose cancer had spread beyond the original cancer site were more likely to develop a TE than those with localized cancer. . Researchers reviewed patient records for 122 children and young adults treated for sarcoma in the Pediatric Oncology Branch of the NCI between October 1980 and July 2002.

Cancer creates an environment that is conducive to thrombosis because of the propensity of tumor cells to promote coagulation as well the secretion of cytokines, or signaling compounds, that trigger inflammation. In addition, factors common to cancer patients, such as chemotherapy, surgery, immobilization, having a central venous access device (such as a central line), and having other diseases or conditions, all increase a person's risk for blood clots.

The study results showed that, over the 22-year study period, 16 percent of children and young adults with sarcoma developed a TE. However, the researchers noted that this figure probably underestimates the true frequency of TEs in this pediatric patient population. Since this was a retrospective study of archival patient records, most of the original physicians may not have specifically looked for TEs, so some blood clots would have gone unrecorded. Also, TEs often are asymptomatic and early screening was less accurate. As the study observed, the rate at which TEs were detected in sarcoma patients increased from 7 percent before 1993 to 23 percent since 1993 -- an increase they attributed to improved screening techniques.

Children whose cancer had spread to other parts of the body were 2.5 times more likely to develop a TE than those whose disease was localized. The most common locations of the blood clots were in the deep veins of the legs and arms, the lungs (pulmonary embolism), and the inferior vena cava, which is the large vein that carries blood from the lower half of the body into the heart. Of the patients who developed a TE, 40 percent had no symptoms related to their blood clot. Thromboses were often detected around the same time as the cancer diagnosis.

Previous research had shown a link between cancer and TEs in adults, but data regarding TEs in adults may not be applicable to children with cancer. Children differ from adults in the types of cancer that occur, as well as in the number and types of co-morbid conditions. The researchers only looked at sarcomas (cancers of the bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue) in children, so not all pediatric cancer types were represented. Sarcomas account for 15 to 20 percent of pediatric cancers and include rhabdomyosarcoma, Ewing sarcoma, and osteosarcoma. Approximately two-thirds of these cases can be cured.

A total of 23 TEs occurred in 19 of the 122 patients during the 22-year period of record keeping. Twenty-three percent of patients with metastatic cancer developed a TE, compared to 10 percent of patients with localized cancer, suggesting an association between tumor burden and the risk of TE.

Senior researcher Alan S. Wayne, M.D., Clinical Director of NCI's Pediatric Oncology Branch at the Center for Cancer Research recommends, "Children and young adults with sarcoma should be closely monitored for thrombosis because these patients may not have any symptoms related to a TE and because thromboembolism is a potentially life-threatening complication that is almost always amenable to therapy."

Article: Paz-Priel I, Long L, Helman L, Mackall C, Wayne A. Thromboembolic Events in Children and Young Adults with Pediatric Sarcoma, Journal of Clinical Oncology. 25 (11).


Story Source:

The above story is based on materials provided by NIH/National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

NIH/National Cancer Institute. "Childhood Sarcoma Increases Risk Of Blood Clots, Researchers Find." ScienceDaily. ScienceDaily, 19 April 2007. <www.sciencedaily.com/releases/2007/04/070418182440.htm>.
NIH/National Cancer Institute. (2007, April 19). Childhood Sarcoma Increases Risk Of Blood Clots, Researchers Find. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2007/04/070418182440.htm
NIH/National Cancer Institute. "Childhood Sarcoma Increases Risk Of Blood Clots, Researchers Find." ScienceDaily. www.sciencedaily.com/releases/2007/04/070418182440.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Raw: Paralyzed Marine Walks With Robotic Braces

Raw: Paralyzed Marine Walks With Robotic Braces

AP (Nov. 21, 2014) Marine Corps officials say a special operations officer left paralyzed by a sniper's bullet in Afghanistan walked using robotic leg braces in a ceremony to award him a Bronze Star. (Nov. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins