Featured Research

from universities, journals, and other organizations

Exercise Can Cut Coronary Artery Disease Risk For Some With Multiple Sclerosis

Date:
April 30, 2007
Source:
American Physiological Society
Summary:
Results of a new study suggest that people with mild to moderate multiple sclerosis (MS) are capable of improving their aerobic fitness levels similar to their non-MS counterparts. While physical inactivity may predispose MS patients to have increased coronary artery disease risk, MS-related symptoms don't preclude this group from potentially reducing their risk factors through exercise.

Results of a new study suggest that people with mild to moderate multiple sclerosis (MS) are capable of improving their aerobic fitness levels similar to their non-MS counterparts. While physical inactivity may predispose MS patients to have increased coronary artery disease risk, MS-related symptoms don't preclude this group from potentially reducing their risk factors through exercise.

Related Articles


Multiple sclerosis (MS) is a degenerative disease affecting the central nervous system of 400,000 Americans with 200 more diagnosed each week. The disease causes reduced nerve function and consequently a variety of symptoms. The most commonly reported symptoms include muscle weakness, spasticity, excess fatigue and depression, which often results in a vicious cycle of reduced mobility and decreased physical activity. Reduced activity level predisposes people with MS to be at increased risk for secondary diseases such as diabetes, osteoporosis and coronary artery disease (CAD).

In an effort to improve the health status of those with MS, a team of researchers worked with individuals diagnosed with mild to moderate disability in an eight week aerobic cycling regimen. The investigators found that people with MS improved their aerobic fitness and reduced their level of CAD risk.

The Study: Summary of Methodology

Eleven MS patients and 11 matched controls (age, sex, body mass index) participated in the study. MS patients were clinically stable and had mild to moderate disability. All volunteers (MS and control subjects) had physician clearance and met specific inclusion/exclusion criteria.

Once enrolled, subjects participated in an eight week supervised aerobic cycling exercise protocol wherein they exercised three days per week. Each exercise session consisted of a three minute warm up at a self-assessed comfortable speed followed by 30 minutes of cycle ergometry (continuous or intermitant) at 60 percent of VO2peak, consistent with the American College of Sports Medicine (ACSM) guidelines for improving health and fitness.

Subjects were assessed for CAD risk before and after the exercise intervention, according to the guidelines of the American Heart Association. Serum samples were obtained the morning after a 12-hour fast, 48 hours before the first and final exercise session of the training program. Enzymatic colorimetric methods were used to analyze serum total cholesterol, high-density and low-density lipoprotein cholesterol, triglycerides and glucose. Anthropometric (body weight, BMI, body fat percentage) measures and blood pressure were also taken at the same time.

Results

The researchers noted that:

  • following the intervention, aerobic fitness improved by 10 percent in MS subjects (Pre: 2.2 0.4 L/min; Post: 2.5 0.4) and 14 percent in controls (Pre: 2.4 1.0 L/min; Post: 2.8 1.0), respectively;
  • baseline assessment of CAD risk factors showed that the MS subjects had significantly higher circulating levels of triglyceride (MS: 5.0 2.2 mmol/L; Control: 1.2 0.05) and total glucose (MS: 7.1 1.1 mmol/L; Control: 6.6 0.5) compared to the control group;
  • after completion of 24 total cycling sessions, MS subjects showed significant reductions in percent body fat, triglycerides and resting diastolic blood pressure. Specifically, there was a 6 percent decrease in percent body fat (pre: 29.6 5.8 percent; post: 27.9 7.6), a 23 percent decrease in triglycerides (pre: 7.75 2.2 mmol/L; post: 5.80 1.8) while diastolic blood pressure dropped 5 mmHg (pre: 80.7 11.1 mmHg; post: 75.0 8.1). Relative improvements in the number of risk factors were observed in 7 of 11 MS participants; and
  • the control subjects showed significant decrease in fasting glucose (pre: 6.6 0.5 mmol/L; post: 5.9 0.4). Additionally, four of 11 subjects reduced their relative CAD risk by at least one risk factor.

Discussion/Conclusions

The results of this study support earlier work done by this research team, which showed exercise was associated with reduced individual CAD risk factors among resistance trained MS subjects. The results suggest that people with mild to moderate MS are capable of improving their aerobic fitness to levels similar to their non-MS counterparts. Thus, while physical inactivity may predispose MS patients to have increased CAD risk, MS-related symptoms do not preclude this group from potentially reducing their risk factors through exercise.

Physiology is the study of how molecules, cells, tissues and organs function to create health or disease. The American Physiological Society (APS) has been an integral part of the scientific discovery process since it was established in 1887.

Reference: These findings are drawn from a study entitled Aerobic Exercise Influence on Coronary Artery Disease Risk Factors in Multiple Sclerosis. It was conducted by Darpan Patel, Vanessa Castellano, Sean McCoy, Ashley Blazina and Lesley White, all of the University of Florida, Department of Applied Physiology and Kinesiology, Gainesville, FL. Patel will present the team's findings at the 120th annual meeting of the American Physiological Society, being held as part of the Experimental Biology conference (EB '07).


Story Source:

The above story is based on materials provided by American Physiological Society. Note: Materials may be edited for content and length.


Cite This Page:

American Physiological Society. "Exercise Can Cut Coronary Artery Disease Risk For Some With Multiple Sclerosis." ScienceDaily. ScienceDaily, 30 April 2007. <www.sciencedaily.com/releases/2007/04/070430074716.htm>.
American Physiological Society. (2007, April 30). Exercise Can Cut Coronary Artery Disease Risk For Some With Multiple Sclerosis. ScienceDaily. Retrieved November 22, 2014 from www.sciencedaily.com/releases/2007/04/070430074716.htm
American Physiological Society. "Exercise Can Cut Coronary Artery Disease Risk For Some With Multiple Sclerosis." ScienceDaily. www.sciencedaily.com/releases/2007/04/070430074716.htm (accessed November 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, November 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com
Ebola: Life Without School in Guinea

Ebola: Life Without School in Guinea

AFP (Nov. 21, 2014) Following the closure of schools and universities in Guinea because of the Ebola virus, students look for temporary work or gather in makeshift classrooms to catch up on their syllabus. Duration: 02:14 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins