Featured Research

from universities, journals, and other organizations

Pancreatic Cancer Markers Identified, May Predict Survival

Date:
May 4, 2007
Source:
Ohio State University
Summary:
Scientists have discovered a way to distinguish pancreatic cancer from non-cancerous tissue, new research shows. The method may also distinguish patients who will survive longer than two years.

Scientists have discovered a way to distinguish pancreatic cancer from non-cancerous tissue, new research shows. The method may also distinguish patients who will survive longer than two years.

Related Articles


The research examined pancreatic cancer cells for tiny molecules called microRNA (miRNA). It shows that relative levels of certain miRNAs can distinguish pancreatic cancer from nearby noncancerous tissue and from inflamed pancreatic tissue.

The study by researchers at Ohio State University Comprehensive Cancer Center, is published in the May 2 issue of the Journal of the American Medical Association. “Our findings suggest that miRNAs might help detect the disease earlier and differentiate it from noncancerous conditions,” says first author Mark Bloomston, assistant professor of surgery at Ohio State's James Cancer Hospital and Solove Research Institute.

“We also found that we could predict which patients would do better or worse based on a just a few miRNAs. Such correlations with survival have previously been lacking in pancreatic cancer,” Bloomston says.

Pancreatic cancer is expected to strike 37,170 Americans and to kill 33,370 others this year, making it the fourth-leading cause of cancer death in both men and women. The number of new cases nearly equals the number of deaths because the disease is difficult to diagnosis early and because there have been few treatment advances.

For this study, Bloomston and his colleagues examined tumor samples from 65 patients with adenocarcinoma of the pancreas, the most common form of the disease. They extracted miRNA from isolated tumor cells and from adjacent noncancerous pancreatic tissue. In addition, they isolated miRNA from the pancreatic cells of people who had undergone surgery for chronic pancreatitis, an inflammation of the pancreas often associated with pancreatic cancer.

Perhaps surprisingly, the miRNAs that could discriminate between long- and short-term survivors were not among those that were specific to pancreatic cancer. “These miRNAs have not been studied much, so we don't know how important they will ultimately be,” Bloomston says. “Our findings are really just a starting point. Now we and others need to validate the role of these molecules in pancreatic cancer and to study what they do.”

MicroRNAs, first discovered less than 15 years ago, help control the type and quantity of proteins that cells naturally make by modifying other genes. Research over the past few years has shown that they also play an important role in cancer. More than 300 different human miRNAs have been identified so far.

Funding from the National Cancer Institute supported this research.


Story Source:

The above story is based on materials provided by Ohio State University. Note: Materials may be edited for content and length.


Cite This Page:

Ohio State University. "Pancreatic Cancer Markers Identified, May Predict Survival." ScienceDaily. ScienceDaily, 4 May 2007. <www.sciencedaily.com/releases/2007/05/070501160628.htm>.
Ohio State University. (2007, May 4). Pancreatic Cancer Markers Identified, May Predict Survival. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2007/05/070501160628.htm
Ohio State University. "Pancreatic Cancer Markers Identified, May Predict Survival." ScienceDaily. www.sciencedaily.com/releases/2007/05/070501160628.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Fauci Says Ebola Risk in US "essentially Zero"

Fauci Says Ebola Risk in US "essentially Zero"

AP (Oct. 30, 2014) NIAID Director Anthony Fauci said the risk of Ebola becoming an epidemic in the U.S. is essentially zero Thursday at the Washington Ideas Forum. He also said an Ebola vaccine will be tested in West Africa in the next few months. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Nurse Defies Ebola Quarantine With Bike Ride

Nurse Defies Ebola Quarantine With Bike Ride

AP (Oct. 30, 2014) A nurse who vowed to defy Maine's voluntary quarantine for health care workers who treated Ebola patients followed through on her promise Thursday, leaving her home for an hour-long bike ride. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Pot-Infused Edibles Raise Concerns in Colorado

Pot-Infused Edibles Raise Concerns in Colorado

AFP (Oct. 30, 2014) Colorado may have legalized marijuana for recreational use, but the debate around the decision still continues, with a recent - failed - attempt to ban cannabis-infused edibles. Duration: 01:53 Video provided by AFP
Powered by NewsLook.com
British Navy Ship Arrives in Sierra Leone With Ebola Aid

British Navy Ship Arrives in Sierra Leone With Ebola Aid

AFP (Oct. 30, 2014) The British ship RFA ARGUS arrived in Sierra Leone to deliver supplies and equipment to help the fight against Ebola. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins