Featured Research

from universities, journals, and other organizations

Sling Surgery Is More Effective Than Burch For Bladder Control In Women

Date:
May 22, 2007
Source:
NIH/National Institute of Diabetes and Digestive and Kidney Diseases
Summary:
In the largest and most rigorous U.S. trial comparing two traditional operations for stress urinary incontinence in women, a team of urologists and urogynecologists has found that a sling procedure helps more women achieve dryness than the Burch technique.

Diagram of sling.
Credit: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health

In the largest and most rigorous U.S. trial comparing two traditional operations for stress urinary incontinence (SUI) in women, a team of urologists and urogynecologists supported by the National Institutes of Health (NIH) has found that a sling procedure helps more women achieve dryness than the Burch technique.

"For the first time, we have a meticulous, relatively long-term comparison of these common surgeries in women," said Leroy M. Nyberg Jr., Ph.D., M.D., director of urology research at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). "Women who participated in this study have made it possible for many women with stress incontinence and their doctors to make more-informed choices based on clear benefits, risks and personal preferences."

The Stress Incontinence Surgical Treatment Efficacy Trial (SISTEr) found that significantly more women with a sling made from the patient's own tissue and placed around the urethra for additional support were dry, compared to women with a Burch colposuspension, in which sutures are attached to a pelvic ligament to support the urethra. Both approaches are illustrated below. Two years after surgery, 47 percent of women who had the sling procedure and 38 percent who had a Burch were dry overall, including leakage that could have been caused by urge incontinence. Considering only stress-specific leakage, 66 percent of women with a sling and 49 percent with a Burch procedure were dry.

SISTEr randomized 655 women with either pure SUI or a combination of stress and urge incontinence to receive a fascial sling or a Burch. Complete information on measures used to assess urinary incontinence was available for 520 participants (79 percent) 24 months after surgery. Quality of life, patient satisfaction and side effects were also studied.

While most women in the study were satisfied with the results of treatment, those with a sling were significantly more satisfied. Eighty-six percent with a sling were satisfied, compared to 78 percent of the Burch group.

Side effects were more common among women with slings, tempering the positive results of the procedure. The most common side effect was urinary tract infections, which occurred in 63 percent of women with a sling and 47 percent of the Burch group. Women with a sling also had more voiding problems (14 percent versus 2 percent) and persistent urge incontinence, the loss of urine just before feeling a strong, sudden urge to empty the bladder (27 percent versus 20 percent). Nineteen women with slings who had difficulty voiding after treatment needed surgery to correct the problem; none in the Burch group needed corrective surgery for voiding problems.

Stress urinary incontinence, in which coughing, laughing, sneezing, running or lifting heavy objects causes urine to leak, is commonly treated with surgery designed to provide additional support to the bladder neck and urethra during increases in abdominal pressure that occur with these kinds of activities. However, randomized, controlled trials comparing these operations are rare. Studies predating SISTEr were small, short-term, or less stringent about diagnostic criteria and outcome measures, producing inconsistent results across studies. SISTEr set a higher bar by standardizing definitions, clinical evaluations, and surgical procedures at all sites and by using "composite outcome measures and a more rigid definition of success compared to other studies," according to the study.

SISTEr defined two levels of treatment success. Stress-specific success required that women have no symptoms of leakage during physical activities, no leakage during a valsalva and cough stress-test, and no re-treatment for the problem. Overall success required that women meet SUI-specific treatment goals, have a negative pad test and have no leakage episodes recorded on a three-day voiding diary.

This higher bar may account for lower success rates in SISTEr than in earlier trials, but it also "establishes a template for conducting surgical trials for urinary incontinence and for other urological conditions," said John W. Kusek, Ph.D., co-director of kidney and urology trials at NIDDK.

NIH's National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Child Health and Human Development and Office of Research on Women's Health funded the Urinary Incontinence Treatment Network, a group of nine clinical centers and a biostatistical center, to conduct a series of rigorous, long-term trials of common incontinence therapies.

Urinary incontinence is a common and costly condition that reduces quality of life for American women. NIDDK's Urologic Diseases in America project reports that up to three-fourths of women have some degree of incontinence, and the direct cost of incontinence for women was $12.4 billion in 1995.

SISTEr is the first trial completed by UITN, with two other studies in the wings. Results of the second trial, the Behavior Enhances Drug Reduction of Incontinence (BE-DRI), for urge incontinence, are expected later this year. BE-DRI asked 307 women to make changes such as emptying the bladder on a regular schedule and to practice Kegel exercises to strengthen pelvic muscles to learn if these common treatments would allow women to stop drug therapy and maintain the same degree of bladder control.

The third UITN study, the Trial of Mid-Urethral Slings (TOMUS), is recruiting patients to compare two minimally invasive surgeries for the treatment of SUI. Both procedures include placement of a synthetic mesh sling and have been approved by FDA for stress incontinence.

References: ME Albo et al. Burch Colposuspension versus Fascial Sling to Reduce Urinary Stress Incontinence. The New England Journal of Medicine 356(21):2143-55 (2007). K Strohbehn. Editorial: Shades of Dry--Curing Urinary Stress Incontinence. The New England Journal of Medicine 356(21):2198-2200 (2007).

The study is being released early by the New England Journal of Medicine (NEJM) to coincide with a presentation at the annual meeting of the American Urological Association on May 21, 2007.


Story Source:

The above story is based on materials provided by NIH/National Institute of Diabetes and Digestive and Kidney Diseases. Note: Materials may be edited for content and length.


Cite This Page:

NIH/National Institute of Diabetes and Digestive and Kidney Diseases. "Sling Surgery Is More Effective Than Burch For Bladder Control In Women." ScienceDaily. ScienceDaily, 22 May 2007. <www.sciencedaily.com/releases/2007/05/070521124530.htm>.
NIH/National Institute of Diabetes and Digestive and Kidney Diseases. (2007, May 22). Sling Surgery Is More Effective Than Burch For Bladder Control In Women. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2007/05/070521124530.htm
NIH/National Institute of Diabetes and Digestive and Kidney Diseases. "Sling Surgery Is More Effective Than Burch For Bladder Control In Women." ScienceDaily. www.sciencedaily.com/releases/2007/05/070521124530.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins