Featured Research

from universities, journals, and other organizations

Gender Impacts Colorectal Cancer Progression

Date:
June 6, 2007
Source:
University of Southern California
Summary:
Physiological differences between men and women may contribute to differential tumor development and progression in colon cancer patients, according to a new study.

Physiological differences between men and women may contribute to differential tumor development and progression in colon cancer patients, a study led by researchers at the University of Southern California (USC) suggests.

"Taking gender into account when examining the genetic profile of patients may help to those who will benefit from specific chemotherapy treatments," says principal investigator Heinz-Josef Lenz, M.D., professor of medicine at USC's Keck School of Medicine.

Findings from the study were displayed on Monday, June 4 at the annual meeting of the American Society of Clinical Oncology (ASCO) held at McCormick Place in Chicago.

The study focused specifically on patients who had been treated with 5-Fluorouracil and oxaliplatin chemotherapy, Lenz says. Researchers were able to identify molecular markers predicting response time to tumor progression and overall survival.

"When we stratified for men and women, different genes appear to be predictive for outcome," says Lenz. "This is the very first study showing that molecular markers may be sex specific."

There has been increasing evidence that gender plays a significant role in the development and progression of colorectal cancer, Lenz explains. Colorectal cancer rates are higher among men, and previous studies have shown a protective effect of female hormones.

Seventy-four female and 78 male patients participated in the study, which analyzed 24 polymorphisms in 12 genes involved in cancer progression. Researchers tested for association of specific polymorphisms with overall survival (OS), time to tumor progression (TTP) and tumor response.

Men carrying polymorphisms in the ER- and SCN1A genes had improved TTP, versus women carrying polymorphisms in the XPD and EGFR genes. Likewise, male patients carrying ER- and MTHFR polymorphisms had improved overall survival, while female patients carrying polymorphisms in SCN1A and PLA2 genes had improved OS.

"These findings are critical since men and women are usually not divided when molecular research is being done," Lenz explains. "Our results suggest for the first time that genomic profiling to predict clinical outcome of patients with metastatic colorectal cancer depends on gender."

Funding for this study come from the San Pedro Guild and Cornelius Pings Memorial Fund.

Michael A. Gordon, Wu Zhang, Dongyun Yang, Fumio Nagashima, Hueng-Moon Chang, Georg Lurje, Eva Borucka and Heinz-Josef Lenz, "Sex-specific genomic profile predicts clinical outcome in metastatic colorectal (mCRC) patients treated with 5-Fluorouracil/Oxaliplatin." Presented at 8 a.m., Monday June 4, 2007.


Story Source:

The above story is based on materials provided by University of Southern California. Note: Materials may be edited for content and length.


Cite This Page:

University of Southern California. "Gender Impacts Colorectal Cancer Progression." ScienceDaily. ScienceDaily, 6 June 2007. <www.sciencedaily.com/releases/2007/06/070604124058.htm>.
University of Southern California. (2007, June 6). Gender Impacts Colorectal Cancer Progression. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2007/06/070604124058.htm
University of Southern California. "Gender Impacts Colorectal Cancer Progression." ScienceDaily. www.sciencedaily.com/releases/2007/06/070604124058.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins