Featured Research

from universities, journals, and other organizations

Genetic Factor Predicts Prognosis In Brain Tumor Patients

Date:
June 27, 2007
Source:
Public Library of Science
Summary:
PLoS ONE has just published a study which defines a gene locus on chromosome 1 that predicts prognosis of brain tumor patients and may even set the basis for the development of more efficient drugs to combat brain cancer. Clinical and basic researchers from the University Hospital Basel, Switzerland, the Heinrich Heine University Düsseldorf, Germany, and the Emory University Atlanta, Ga., USA have defined the Notch2 gene as candidate gene for brain tumor development.

PLoS ONE has just published a study which defines a gene locus on chromosome 1 that predicts prognosis of brain tumor patients and may even set the basis for the development of more efficient drugs to combat brain cancer. Clinical and basic researchers from the University Hospital Basel, Switzerland, the Heinrich Heine University Düsseldorf, Germany, and the Emory University Atlanta, USA have defined the Notch2 gene as candidate gene for brain tumor development. The study was coordinated by Adrian Merlo, neurosurgeon at the University Hospital Basel.

Related Articles


The Notch2 locus highly predicts survival in subgroups of brain tumor patients. This gene is an important regulator of developmental processes. Taking advantage of a complex DNA duplication involving the Notch2 gene, the researchers developed a molecular assay that unambiguously distinguishes prognostically favorable brain tumor cases from cases that show rapid tumor progression.

In ongoing studies, the Basel researchers, supported by Ruth Chiquet from the Friedrich Miescher Institute, have found that Notch2 upregulates the tenascin-C gene which is well known to play a critical role in brain tumorigenesis. This new brain tumor pathway does not only offer precise diagnostic information, but also defines new targets for molecular intervention to develop drugs against this severe human disease.

Citation: Boulay J-L, Miserez AR, Zweifel C, Sivasankaran B, Kana V, et al (2007) Loss of NOTCH2 Positively Predicts Survival in Subgroups of Human Glial Brain Tumors. PLoS ONE 2(6): e576. doi:10.1371/journal.pone.0000576 (http://www.plosone.org/doi/pone.0000576)


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Genetic Factor Predicts Prognosis In Brain Tumor Patients." ScienceDaily. ScienceDaily, 27 June 2007. <www.sciencedaily.com/releases/2007/06/070627091626.htm>.
Public Library of Science. (2007, June 27). Genetic Factor Predicts Prognosis In Brain Tumor Patients. ScienceDaily. Retrieved January 25, 2015 from www.sciencedaily.com/releases/2007/06/070627091626.htm
Public Library of Science. "Genetic Factor Predicts Prognosis In Brain Tumor Patients." ScienceDaily. www.sciencedaily.com/releases/2007/06/070627091626.htm (accessed January 25, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, January 25, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) — The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) — Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) — Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) — A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins