Featured Research

from universities, journals, and other organizations

New Ferret Model May Measure Pandemic Potential Of H5N1 Influenza Viruses In Humans

Date:
July 17, 2007
Source:
American Society for Microbiology
Summary:
Researchers from the U.S. and abroad used a contact ferret model to evaluate transmissibility of influenza viruses in humans and found that some strains currently circulating throughout the world may transmit better than others in mammals.

The study found that both Vietnam “avian-like” viruses caused neurological symptoms and death in ferrets while the Hong Kong and Turkey “human-like” viruses caused only mild non-lethal symptoms.
Credit: iStockphoto/Elizabeth Parodi

Researchers from the U.S. and abroad used a contact ferret model to evaluate transmissibility of influenza viruses in humans and found that some strains currently circulating throughout the world may transmit better than others in mammals. The researchers report their findings in the July 2007 issue of the Journal of Virology.

Transmission of H5N1 influenza viruses is of great concern worldwide as their geographic and host ranges continue to expand. Currently transmission to humans has been inefficient. Although there is limited knowledge of potential routes and determinants required for transmission, researchers predict genetic reassortment and mutation during adaptation in the host to be the two most likely avenues.

In the study experimental groups consisting of one inoculated ferret and two contact ferrets were used to monitor the transmissibility of four human H5N1 viruses isolates collected in Hong Kong (A/Hong Kong/213/03), Vietnam (A/Vietnam/1203/04 and A/Vietnam/JP36-2/05) and Turkey (A/Turkey/65-596/06) between 2003 and 2006. The selected isolates differed in their pathogenicity and affinity for “avian-like” and “human-like” receptors.

Results showed that one contact ferret developed neutralizing antibodies to A/Hong Kong/213/03 but did not exhibit clinical signs or virus shedding. In two of the groups two contact ferrets had detectable virus following 6 to 8 days exposure with the A/Vietnam/JP36-2/05 virus-inoculated ferrets. Infected contact ferrets displayed severe clinical signs despite little or no virus detection in nasal washes. The absence of secondary transmission among ferrets housed together was attributed to minimal virus shedding. The effect of viral pathogenicity and receptor binding specificity on transmissibility showed that both Vietnam “avian-like” viruses caused neurological symptoms and death in ferrets while the Hong Kong and Turkey “human-like” viruses caused only mild non-lethal symptoms.

“Here we demonstrated a useful animal model system to evaluate the transmissibility of H5N1 viruses,” say the researchers. “We propose that future selection of H5N1 vaccine candidates among new antigenic variants should take into account the transmissibility of the virus.”

Reference: H.L. Yen, A.S. Lipatov, N.A. Ilyushina, E.A. Govorkova, J. Franks, N. Yilmaz, A. Douglas, A. Hay, S. Krauss, J.E. Rehg, E. Hoffmann, R.G. Webster. 2007. Inefficient transmission of H5N1 influenza viruses in a ferret contact model. Journal of Virology, 81. 13: 6890-6898


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Microbiology. "New Ferret Model May Measure Pandemic Potential Of H5N1 Influenza Viruses In Humans." ScienceDaily. ScienceDaily, 17 July 2007. <www.sciencedaily.com/releases/2007/07/070716191800.htm>.
American Society for Microbiology. (2007, July 17). New Ferret Model May Measure Pandemic Potential Of H5N1 Influenza Viruses In Humans. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2007/07/070716191800.htm
American Society for Microbiology. "New Ferret Model May Measure Pandemic Potential Of H5N1 Influenza Viruses In Humans." ScienceDaily. www.sciencedaily.com/releases/2007/07/070716191800.htm (accessed October 21, 2014).

Share This



More Plants & Animals News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

White Lion Cubs Born in Belgrade Zoo

White Lion Cubs Born in Belgrade Zoo

AFP (Oct. 20, 2014) Two white lion cubs, an extremely rare subspecies of the African lion, were recently born at Belgrade Zoo. They are being bottle fed by zoo keepers after they were rejected by their mother after birth. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Traditional Farming Methods Gaining Ground in Mali

Traditional Farming Methods Gaining Ground in Mali

AFP (Oct. 20, 2014) He is leading a one man agricultural revolution in Mali - Oumar Diatabe uses traditional farming methods to get the most out of his land and is teaching others across the country how to do the same. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Goliath Spider Will Give You Nightmares

Goliath Spider Will Give You Nightmares

Buzz60 (Oct. 20, 2014) An entomologist stumbled upon a South American Goliath Birdeater. With a name like that, you know it's a terrifying creepy crawler. Sean Dowling (@SeanDowlingTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Adorable Video of Baby Rhino and Lamb Friend Playing

Adorable Video of Baby Rhino and Lamb Friend Playing

Buzz60 (Oct. 20, 2014) Gertjie the Rhino and Lammie the Lamb are teaching the world about animal conservation and friendship. TC Newman (@PurpleTCNewman) has the adorable video! Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins