Featured Research

from universities, journals, and other organizations

High Nonfasting Triglyceride Levels Associated With Increased Risk For Cardiovascular Events

Date:
July 20, 2007
Source:
JAMA and Archives Journals
Summary:
Results from two studies indicate that elevated nonfasting triglyceride levels are associated with cardiovascular events such as a heart attack, with one study finding that triglyceride levels measured after fasting does not show this association, according to studies in the July 18 issue of JAMA.

Results from two studies indicate that elevated nonfasting triglyceride levels are associated with cardiovascular events such as a heart attack, with one study finding that triglyceride levels measured after fasting does not show this association, according to studies in the July 18 issue of JAMA.

Triglyceride levels are usually measured in the fasting state, which could exclude certain types of lipoprotein particles ("remnant" lipoproteins), a possible risk factor for atherosclerosis, according to background information in the article. However, except for the first hours in the early morning, most individuals are in the nonfasting state most of the time. "Atherosclerosis may be a postprandial [occurring after a meal] phenomenon in which remnant lipoproteins play a dominant role. If this is true, increased levels of nonfasting triglycerides, reflecting increased levels of remnant lipoproteins, may predict risk of myocardial infarction (MI; heart attack), ischemic heart disease (IHD), and death," the authors write.

Børge G. Nordestgaard, M.D., D.M.Sc., of Herlev University Hospital, Herlev, Denmark, and colleagues tested the hypothesis that very high levels of nonfasting triglycerides are associated with an increased risk of heart attack, IHD, and death in the general population. The study included 7,587 women and 6,394 men from the general population of Copenhagen, age 20 to 93 years, who were followed up from baseline (1976-1978) until 2004 (average follow-up 26 years).

The researchers found that with increasing levels of nonfasting triglycerides, levels of remnant lipoprotein cholesterol increased. During the follow-up, 1,793 participants experienced a heart attack, 3,479 developed IHD, and 7,818 died. In men and women, the cumulative incidence of heart attack, IHD, and death increased with increasing levels of nonfasting triglyceride levels.

Among women, the adjusted risk for heart attack increased for each higher category of triglyceride levels (from 1-mmol/L to greater than 5-mmol/L), with the increase in risk (adjusted for other factors) ranging from 1.7 times to 5.4 times, compared to those with triglyceride levels of less than 1-mmol/L. For men, the increased adjusted risk for heart attack for each higher category of triglyceride levels ranged from 1.4 to 2.4. Risk of IHD and death also generally increased with higher triglyceride levels.

"We found that nonfasting triglyceride levels independently predict MI, IHD, and death, particularly in women. These findings may reflect the effects of remnant lipoproteins and therefore may be of considerable interest when designing future trials of agents aimed at reducing triglyceride levels or attenuating atherogenic metabolic abnormalities. If our findings are confirmed, clinical care might be simplified by using nonfasting lipid profiles for atherosclerosis risk prediction," the researchers conclude.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Cite This Page:

JAMA and Archives Journals. "High Nonfasting Triglyceride Levels Associated With Increased Risk For Cardiovascular Events." ScienceDaily. ScienceDaily, 20 July 2007. <www.sciencedaily.com/releases/2007/07/070718002640.htm>.
JAMA and Archives Journals. (2007, July 20). High Nonfasting Triglyceride Levels Associated With Increased Risk For Cardiovascular Events. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2007/07/070718002640.htm
JAMA and Archives Journals. "High Nonfasting Triglyceride Levels Associated With Increased Risk For Cardiovascular Events." ScienceDaily. www.sciencedaily.com/releases/2007/07/070718002640.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) — Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) — NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com
How to Master Motherhood With the Best Work/Life Balance

How to Master Motherhood With the Best Work/Life Balance

TheStreet (Apr. 22, 2014) — In the U.S., there are more than 11 million couples trying to conceive at any given time. From helping celebrity moms like Bethanny Frankel to ordinary soon-to-be-moms, TV personality and parenting expert, Rosie Pope, gives you the inside scoop on mastering motherhood. London-born entrepreneur Pope is the creative force behind Rosie Pope Maternity and MomPrep. She explains why being an entrepreneur offers the best life balance for her and tips for all types of moms. Video provided by TheStreet
Powered by NewsLook.com
Catching More Than Fish: Ugandan Town Crippled by AIDS

Catching More Than Fish: Ugandan Town Crippled by AIDS

AFP (Apr. 22, 2014) — The village of Kasensero on the shores of Lake Victoria was where HIV-AIDS was first discovered in Uganda. Its transient population of fishermen and sex workers means the nationwide programme to combat the virus has had little impact. Duration: 02:30 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins