Featured Research

from universities, journals, and other organizations

Keeping Killer T Cells Under Control In The Liver

Date:
July 23, 2007
Source:
Journal of Clinical Investigation
Summary:
Natural killer (NK) T cells (of which type I and type II exist) are a small group of T cells in the blood that recognize and bind self- and foreign lipids. They rapidly release cytokines that can promote or suppress different immune responses, however the regulation of these responses is not well understood.

Natural killer (NK) T cells (of which type I and type II exist) are a small group of T cells in the blood that recognize and bind self- and foreign lipids. They rapidly release cytokines that can promote or suppress different immune responses, however the regulation of these responses is not well understood.

In a study appearing online on July 19 in advance of publication in the August print issue of the Journal of Clinical Investigation, Vipin Kumar and colleagues from the Torrey Pines Institute for Molecular Studies examined the responses of these cells following their recognition of a self-glycolipid, sulfatide, and their relevance to inflammatory liver disease.

They show that activation of sulfatide-reactive type II NKT cells caused recruitment of type I NKT cells into the liver in mice. These recruited type I NKT cells were anergic (ie. they were not able to mount a normal immune response against this self antigen) and as such were able to prevent experimentally-induced hepatitis in these animals.

The authors went on to show that secretion of the cytokine IL-12 by dendritic cells in the liver and interaction of these dendritic cells with type II NKT cells was able to regulate the activity of type I NKT cells. The authors suggest that this activity could be exploited for the purpose of devising therapeutic interventions for inflammatory disease, including autoimmune diseases and asthma.

Article: Type II NKT cell--mediated anergy induction in type I NKT cells prevents inflammatory liver disease


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Keeping Killer T Cells Under Control In The Liver." ScienceDaily. ScienceDaily, 23 July 2007. <www.sciencedaily.com/releases/2007/07/070719192312.htm>.
Journal of Clinical Investigation. (2007, July 23). Keeping Killer T Cells Under Control In The Liver. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2007/07/070719192312.htm
Journal of Clinical Investigation. "Keeping Killer T Cells Under Control In The Liver." ScienceDaily. www.sciencedaily.com/releases/2007/07/070719192312.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins