Featured Research

from universities, journals, and other organizations

Activation Of Liver X Receptor-Beta Lowers Cholesterol And Reverses Atherosclerosis

Date:
July 30, 2007
Source:
Journal of Clinical Investigation
Summary:
A new study shows that activation of LXR-beta by a synthetic compound is able to reverse atherosclerosis and cholesterol overload in mice.

In animals and humans, the proteins known as liver X receptors (LXRs) sense cholesterol levels. Upon sensing increases in cholesterol, these receptors activate signaling pathways that remove diet-derived cholesterol from the body. Two types of LXRs – LXR-alpha and LXR-beta – are therefore potential targets for the development of anti-atherosclerosis drugs.

However, the effects of synthetic drugs that activate these two receptors have not been well studied.

In a study appearing online on July 26 in advance of publication in the August print issue of the Journal of Clinical Investigation, Peter Tontonoz and colleagues from the University of California, Los Angeles, show that activation of LXR-beta by a synthetic compound is able to reverse atherosclerosis and cholesterol overload in mice.

The authors began by studying mice lacking apolipoprotein E (apoE; a protein that functions in cholesterol distribution among cells), which have increased cholesterol levels and are predisposed to develop atherosclerosis. They showed that the loss of LXR-alpha in these animals results in a striking body-wide accumulation of cholesterol and accelerated atherosclerosis.

This observation suggests that LXR-beta alone is unable to maintain homeostasis under conditions of cholesterol overload. Surprisingly, however, administration of a synthetic compound that activates LXR-beta, was able to compensate for the loss of LXR-alpha, reduce cholesterol overload and reduce atherosclerosis.

The results of the study suggests that LXR-alpha has an essential role in maintaining cholesterol homeostasis in conditions of cholesterol overload such as hypercholesterolemia and lend support to the notion that future drug development studies should examine targeting LXR-beta.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Activation Of Liver X Receptor-Beta Lowers Cholesterol And Reverses Atherosclerosis." ScienceDaily. ScienceDaily, 30 July 2007. <www.sciencedaily.com/releases/2007/07/070726185424.htm>.
Journal of Clinical Investigation. (2007, July 30). Activation Of Liver X Receptor-Beta Lowers Cholesterol And Reverses Atherosclerosis. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2007/07/070726185424.htm
Journal of Clinical Investigation. "Activation Of Liver X Receptor-Beta Lowers Cholesterol And Reverses Atherosclerosis." ScienceDaily. www.sciencedaily.com/releases/2007/07/070726185424.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins