Featured Research

from universities, journals, and other organizations

Neural Damage Provoked By Ecstasy Is Related To Ambient Temperature At Which It Is Consumed

Date:
August 7, 2007
Source:
Basque Research
Summary:
There exists a direct relationship between the consumption of MDMA, or ecstasy, at a high ambient temperature and an increase in the neural damage which this drug provokes.

There exists a direct relationship between the consumption of MDMA, or Ecstasy, at a high ambient temperature and an increase in the neural damage which this drug provokes. This was the conclusion of the research carried out by Beatriz Go๑i at the School of Pharmacy of the University of Navarra.

Related Articles


These results form part of her doctoral dissertation, entitled “A Study of the Neurotoxicity Mechanism of 3.4-methylenedioxy-N-methylamphetamine (MDMA or ‘Ecstasy’) after its Administration in Rats: New Responses to Old Questions.”

By means of this study, the researcher was able to relate for the first time the body temperature of the user with a higher metabolism of this substance. There are two factors which, when they co-occurcan produce malignant hyperthermia, a disorder which can sometimes be fatal.

In order to come to this conclusion, the Pamplonan pharmaceutical specialist administered the drug to rats at ambient temperatures of 15, 21 and 30 degrees centigrade. After performing the pertinent analyses, she demonstrated that metabolism of Ecstasy is accelerated by higher ambient temperatures at the time of administration. In addition, higher ambient temperatures also increase, in the same proportion, the neurochemical deficit that affects the brains of the users of this drug.

Higher Risk in Closed Establishments

According to Beatriz Go๑i, the author of the study undertaken at the University of Navarra, the discoveries of this research project acquire more relevance precisely because Ecstasy is typically taken in closed environments, with lots of people and poor ventilation, due to which factors the temperature tends to be quite high.

In addition, she notes that the neural damage provoked by this substance, and which originally was only observed in rats, has already been demonstrated in humans, who appear to suffer severe damage to the serotoninergenic neurons, which are involved in processes as basic as sleep, appetite and mood regulation.

Finally, the pharmaceutical specialist noted that the damage caused by the consumption of MDMA is dependent upon its being metabolized after to its ingestion, since if it were administered directly to the brain, neuronal damage would not occur.


Story Source:

The above story is based on materials provided by Basque Research. Note: Materials may be edited for content and length.


Cite This Page:

Basque Research. "Neural Damage Provoked By Ecstasy Is Related To Ambient Temperature At Which It Is Consumed." ScienceDaily. ScienceDaily, 7 August 2007. <www.sciencedaily.com/releases/2007/08/070803092825.htm>.
Basque Research. (2007, August 7). Neural Damage Provoked By Ecstasy Is Related To Ambient Temperature At Which It Is Consumed. ScienceDaily. Retrieved November 25, 2014 from www.sciencedaily.com/releases/2007/08/070803092825.htm
Basque Research. "Neural Damage Provoked By Ecstasy Is Related To Ambient Temperature At Which It Is Consumed." ScienceDaily. www.sciencedaily.com/releases/2007/08/070803092825.htm (accessed November 25, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Tuesday, November 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) — Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) — Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) — Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins