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New Drug Delivery System Minimizes Side Effects

Date:
August 8, 2007
Source:
Queen's University, Belfast
Summary:
A new drug dosing system controlled by light has just been developed. The system could allow the long-sought ability to deliver drugs where, when, and in the exact doses, required. This would maximize their effect and reduce side effects and damage to healthy parts of the body.
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In the future, novel medicines that are activated by light could reduce side-effects associated with drug delivery, researchers say. Experimental light-activated solution (left) undergoes transformation (right) after exposure to ultraviolet light.
Credit: Courtesy of Colin McCoy, Queen's University Belfast

A new drug dosing system controlled by light has been developed by scientists at Queen’s University Belfast. The system could allow the long-sought ability to deliver drugs where, when, and in the exact doses, required. This would maximize their effect and reduce side effects and damage to healthy parts of the body.

Dr Colin P. McCoy and colleagues from the School of Pharmacy at Queen’s describe their new molecular-scale dosing devices as “a new paradigm for precise control of drug dosing using light.”

The devices consist of medications combined with certain chemical compounds that respond to light in ways that release precisely controlled amounts of the drug. Drug release begins when light falls on the compounds, and lasts only as long as the light continues to shine.

Their study, which is reported in the Journal of the American Chemical Society, showed successful laboratory tests of the system in the controlled release of three common medications used to treat pain and inflammation — aspirin, ibuprofen and ketoprofen.

Explaining some of the potential uses for the new method, Dr McCoy said: “One potential use we cited in the study would be in the treatment of urinary catheter infections, where the drug is held latently in the catheter, and is released when needed using light from a fibre optic. The system could likewise be used for other conditions using an implant under the skin for precisely controlled drug dosing.”

Article: "Light-Triggered Molecule-Scale Drug Dosing Devices"


Story Source:

The above post is reprinted from materials provided by Queen's University, Belfast. Note: Materials may be edited for content and length.


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Queen's University, Belfast. "New Drug Delivery System Minimizes Side Effects." ScienceDaily. ScienceDaily, 8 August 2007. <www.sciencedaily.com/releases/2007/08/070805130108.htm>.
Queen's University, Belfast. (2007, August 8). New Drug Delivery System Minimizes Side Effects. ScienceDaily. Retrieved September 2, 2015 from www.sciencedaily.com/releases/2007/08/070805130108.htm
Queen's University, Belfast. "New Drug Delivery System Minimizes Side Effects." ScienceDaily. www.sciencedaily.com/releases/2007/08/070805130108.htm (accessed September 2, 2015).

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