Featured Research

from universities, journals, and other organizations

Specific Antagonism Lowers Blood Pressure

Date:
August 21, 2007
Source:
Journal of Clinical Investigation
Summary:
High blood pressure is associated with an increased risk of heart attack and stroke. A new study now shows that antagonists of a receptor known as EP1 reduce hypertension in mice and rats. The authors therefore suggest that targeting the PGE2 receptor EP1 might be a viable approach to treating hypertension.

High blood pressure (hypertension) is associated with an increased risk of heart attack and stroke, and the frequent use of drugs known as NSAIDs, for example to treat individuals with rheumatoid arthritis, can cause hypertension.

Exactly why NSAIDs cause hypertension is not clear because they inhibit the generation of several soluble factors (known as prostaglandins) that can affect blood pressure and the effects of inhibiting the individual receptors for prostaglandins are not known. In an attempt to address this issue researchers from Vanderbilt University Medical Center identified a novel potential target for the treatment of hypertension.

In the study, which appears online on August 16 in advance of publication in the September print issue of the Journal of Clinical Investigation, Matthew Breyer and colleagues show that inhibitors of the prostaglandin E2 receptor EP1 reduce hypertension in rats. Consistent with this, mice lacking EP1 were protected from the hypertensive effects of angiotensin II and EP1-specific agonists.

The authors therefore suggest that targeting the PGE2 receptor EP1 might be a viable approach to treating hypertension.

Article: Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Specific Antagonism Lowers Blood Pressure." ScienceDaily. ScienceDaily, 21 August 2007. <www.sciencedaily.com/releases/2007/08/070817102033.htm>.
Journal of Clinical Investigation. (2007, August 21). Specific Antagonism Lowers Blood Pressure. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2007/08/070817102033.htm
Journal of Clinical Investigation. "Specific Antagonism Lowers Blood Pressure." ScienceDaily. www.sciencedaily.com/releases/2007/08/070817102033.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
More People Diagnosed With TB In 2013, But There's Good News

More People Diagnosed With TB In 2013, But There's Good News

Newsy (Oct. 22, 2014) The World Health Organizations says TB numbers rose in 2013, but it's partly due to better detection and more survivors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins