Featured Research

from universities, journals, and other organizations

Progress Understanding Vision Loss Due To Abnormal Network Of Blood Vessels In The Eye

Date:
August 22, 2007
Source:
Journal of Clinical Investigation
Summary:
Many millions of individuals worldwide suffer from vision loss as a result of the formation of an abnormal network of blood vessels in the eye. This abnormal blood vessel network forms in response to damage to the retina and often occurs in individuals who are diabetic. Understanding the molecular mechanisms controlling the development of the network of blood vessels in the retina under normal and pathological conditions is therefore an area of intensive research.

Many millions of individuals worldwide suffer from vision loss as a result of the formation of an abnormal network of blood vessels in the eye. This abnormal blood vessel network forms in response to damage to the retina and often occurs in individuals who are diabetic. Understanding the molecular mechanisms controlling the development of the network of blood vessels in the retina under normal and pathological conditions is therefore an area of intensive research.

Related Articles


In a study appearing online on August 16, in advance of publication in the September print issue of the Journal of Clinical Investigation, Timothy Hla and colleagues from the University of Connecticut School of Medicine, Farmington, show that under normal conditions, blood vessel development is indistinguishable in wild-type mice and in mice lacking a protein known as sphingosine -1-phosphate receptor 2 (S1P2R). By contrast, damage to the retina, in the form of low levels of oxygen, induces the formation of an abnormal network of blood vessels in the eyes of wild-type mice, but not in the eyes of S1P2R-deficient mice.

The absence of pathological blood vessel formation in S1P2R-deficient mice was associated with decreased inflammatory cell infiltration of the retina and decreased expression of the proinflammatory enzyme cyclooxygenase-2. This demonstration that S1P2R-driven inflammation is an important event in pathological blood vessel formation in the eye led the authors to suggest that inhibiting S1P2R activation in the retina might provide a new therapeutic approach to treating diseases of the eye caused by the presence of an abnormal blood vessel network.

Article: Essential role of sphingosine -1- phosphate receptor 2 in pathological angiogenesis of the mouse retina


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Progress Understanding Vision Loss Due To Abnormal Network Of Blood Vessels In The Eye." ScienceDaily. ScienceDaily, 22 August 2007. <www.sciencedaily.com/releases/2007/08/070818084751.htm>.
Journal of Clinical Investigation. (2007, August 22). Progress Understanding Vision Loss Due To Abnormal Network Of Blood Vessels In The Eye. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2007/08/070818084751.htm
Journal of Clinical Investigation. "Progress Understanding Vision Loss Due To Abnormal Network Of Blood Vessels In The Eye." ScienceDaily. www.sciencedaily.com/releases/2007/08/070818084751.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins