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Diabetes: Expanding Beta-cell Numbers

Date:
September 12, 2007
Source:
Journal of Clinical Investigation
Summary:
The underlying cause of both type 1 and type 2 diabetes is that there are insufficient pancreatic beta-cells to control the level of glucose in the blood. Given its potential impact on the treatment of diabetes, deciphering the molecular pathways that control beta-cell proliferation is an area of intensive investigation. In a new study scientists show that the protein Skp2 has a critical role in regulating beta-cell proliferation in mice.

The underlying cause of both type 1 and type 2 diabetes is that there are insufficient pancreatic beta-cells to control the level of glucose in the blood.

Given its potential impact on the treatment of diabetes, deciphering the molecular pathways that control beta-cell proliferation is an area of intensive investigation.

In a new study, Anil Bhushan and colleagues from the David Geffen School of Medicine, Los Angeles, show that the protein Skp2 has a critical role in regulating beta-cell proliferation in mice.

The authors observed that mice lacking Skp2 developed more severe insulin resistance and more overt diabetes after being fed a high-fat diet than normal mice. This was associated with decreased degradation of p27 in beta-cells, which prevented the cells from proliferating.

The authors therefore suggest that Skp2-mediated p27 degradation in beta-cells might have a role in regulating beta-cell proliferation in response to metabolic needs.

Article: Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta-cells, Journal Of Clinical Investigation


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The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


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Journal of Clinical Investigation. "Diabetes: Expanding Beta-cell Numbers." ScienceDaily. ScienceDaily, 12 September 2007. <www.sciencedaily.com/releases/2007/09/070907110407.htm>.
Journal of Clinical Investigation. (2007, September 12). Diabetes: Expanding Beta-cell Numbers. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2007/09/070907110407.htm
Journal of Clinical Investigation. "Diabetes: Expanding Beta-cell Numbers." ScienceDaily. www.sciencedaily.com/releases/2007/09/070907110407.htm (accessed April 18, 2014).

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