Featured Research

from universities, journals, and other organizations

Diabetes: Expanding Beta-cell Numbers

Date:
September 12, 2007
Source:
Journal of Clinical Investigation
Summary:
The underlying cause of both type 1 and type 2 diabetes is that there are insufficient pancreatic beta-cells to control the level of glucose in the blood. Given its potential impact on the treatment of diabetes, deciphering the molecular pathways that control beta-cell proliferation is an area of intensive investigation. In a new study scientists show that the protein Skp2 has a critical role in regulating beta-cell proliferation in mice.

The underlying cause of both type 1 and type 2 diabetes is that there are insufficient pancreatic beta-cells to control the level of glucose in the blood.

Related Articles


Given its potential impact on the treatment of diabetes, deciphering the molecular pathways that control beta-cell proliferation is an area of intensive investigation.

In a new study, Anil Bhushan and colleagues from the David Geffen School of Medicine, Los Angeles, show that the protein Skp2 has a critical role in regulating beta-cell proliferation in mice.

The authors observed that mice lacking Skp2 developed more severe insulin resistance and more overt diabetes after being fed a high-fat diet than normal mice. This was associated with decreased degradation of p27 in beta-cells, which prevented the cells from proliferating.

The authors therefore suggest that Skp2-mediated p27 degradation in beta-cells might have a role in regulating beta-cell proliferation in response to metabolic needs.

Article: Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta-cells, Journal Of Clinical Investigation


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Diabetes: Expanding Beta-cell Numbers." ScienceDaily. ScienceDaily, 12 September 2007. <www.sciencedaily.com/releases/2007/09/070907110407.htm>.
Journal of Clinical Investigation. (2007, September 12). Diabetes: Expanding Beta-cell Numbers. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2007/09/070907110407.htm
Journal of Clinical Investigation. "Diabetes: Expanding Beta-cell Numbers." ScienceDaily. www.sciencedaily.com/releases/2007/09/070907110407.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins