Featured Research

from universities, journals, and other organizations

Gene Abnormality Tied To Getting Parkinson's Disease At A Younger Age

Date:
September 18, 2007
Source:
American Academy of Neurology
Summary:
People with a certain gene mutation are more likely to get Parkinson's disease before the age of 50 compared to those without the gene abnormality, according to a new study. The study found 14 percent of the people with Parkinson's disease carried mutations in the GBA gene compared to only five percent of people without the disease. The gene abnormality was found in 22 percent of people who were diagnosed with Parkinson's disease before age 50 compared to 10 percent of the people with disease onset after age 50.

People with a certain gene mutation are more likely to get Parkinson's disease before the age of 50 compared to those without the gene abnormality, according to a study published in the September 18, 2007, issue of Neurology®, the medical journal of the American Academy of Neurology.

Related Articles


For the study, researchers analyzed the genes of 278 people with Parkinson's disease and 179 people without the disease.

The study found 14 percent of the people with Parkinson's disease carried mutations in the glucocerebrosidase (GBA) gene compared to only five percent of people without the disease. The gene abnormality was found in 22 percent of people who were diagnosed with Parkinson's disease before age 50 compared to 10 percent of the people with disease onset after age 50. Mutations in the GBA gene cause Gaucher's disease, which is a rare disorder that prevents organs, such as the spleen and brain, from working properly due to the build-up of a fatty substance called glucocerebroside.

"Our results confirm that GBA mutations are risk factors for Parkinson's disease and may lead to getting the disease at a younger age," said study author Lorraine N. Clark, PhD, and coauthor Karen Marder, MD, MPH, with Columbia University's Taub Institute for Research on Alzheimer's Disease and the Aging Brain, and Departments of Pathology and Neurology, in New York. "We found those people with GBA mutations developed Parkinson's disease nearly two years earlier than people without the gene abnormality."

The study also looked at how Jewish ancestry affected the likelihood of getting Parkinson's disease at an earlier age since some studies have found people with Jewish ancestry are more likely to have GBA mutations.

Of those with Parkinson's disease, researchers found the gene abnormality in 17 percent of the participants with Jewish ancestry compared to only eight percent of those without Jewish ancestry, suggesting that it may be an important risk factor in people with Jewish ancestry.

The study was supported by grants from the National Institutes of Health and the Parkinson's Disease Foundation.


Story Source:

The above story is based on materials provided by American Academy of Neurology. Note: Materials may be edited for content and length.


Cite This Page:

American Academy of Neurology. "Gene Abnormality Tied To Getting Parkinson's Disease At A Younger Age." ScienceDaily. ScienceDaily, 18 September 2007. <www.sciencedaily.com/releases/2007/09/070917173159.htm>.
American Academy of Neurology. (2007, September 18). Gene Abnormality Tied To Getting Parkinson's Disease At A Younger Age. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2007/09/070917173159.htm
American Academy of Neurology. "Gene Abnormality Tied To Getting Parkinson's Disease At A Younger Age." ScienceDaily. www.sciencedaily.com/releases/2007/09/070917173159.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) — It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) — More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) — In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) — The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins