Featured Research

from universities, journals, and other organizations

Hormone-driven Effects On Eating, Stress Mediated By Same Brain Region

Date:
September 29, 2007
Source:
University of Wisconsin-Madison
Summary:
A hormone system linked to reducing food consumption appears to do so by increasing stress-related behaviors, according to a new study. "With the increasing focus on obesity, people are interested in finding targets that can be used to develop drugs that will reduce appetite and food intake without a lot of side effects," according to one of the scientists.

A hormone system linked to reducing food consumption appears to do so by increasing stress-related behaviors, according to a new study.

Mediated by a hormone receptor protein known as the corticotropin-releasing factor type 2 (CRF2) receptor, the system has attracted recent interest for its role in regulating food intake, say Vaishali Bakshi and Ned Kalin, professors in the Department of Psychiatry at the University of Wisconsin-Madison School of Medicine and Public Health.

"With the increasing focus on obesity, people are interested in finding targets that can be used to develop drugs that will reduce appetite and food intake without a lot of side effects," Bakshi says.

Previous studies have shown that activation of this receptor decreases the amount of food voluntarily eaten by hungry rats, an effect called induced anorexia. This finding led some researchers to suggest that the CRF2 receptor system might be a promising target for therapies to combat obesity.

However, the new study, appearing Sept. 26 in the Journal of Neuroscience, shows that CRF2 receptors in a single brain region, the lateral septum, mediate both feeding and behaviors associated with stress, suggesting this protein may not be an ideal therapeutic target.

By selectively stimulating the CRF2 receptors in the lateral septum, Bakshi and her colleagues found that the treated rats ate less overall - roughly half as much as untreated rats - because they spent less time at it.

"The reason that the rats were eating less after having CRF2 receptors stimulated in the lateral septum was because instead of eating they were spending most of their time exhibiting stress-like behaviors," such as excessive grooming, which Bakshi says has been proposed to represent a type of coping behavior.

In addition, the eating suppression may be secondary to the apparent stress-inducing effects of the receptor. "We found anxiety-like responses at smaller doses than those required to get the reduction in feeding," Bakshi says. "In terms of the chicken and the egg, it suggests that maybe the stress comes first and that the reduction in feeding comes second."

The role of CRF2 receptors in stress responses does not come as a complete surprise, Bakshi says, because the related protein CRF1 receptor exerts similar influences in a different brain region and has been studied for its involvement in anxiety disorders and clinical depression.

However, the finding does suggest that the CRF2 receptor pathway is not likely to be a good choice for the hoped-for obesity treatment.

"This is a cautionary tale," says Bakshi. "We're refuting a global statement that CRF2 stimulation reduces ingestive behavior without eliciting stress-like effects."

The work was carried out in the lab of Ned Kalin and other authors on the study include Sarah Newman, Stephanie Smith-Roe, and Kimberly Jochman. The work was supported by grants from the UW HealthEmotions Research Institute, Meriter Hospital, and the National Institutes of Health.


Story Source:

The above story is based on materials provided by University of Wisconsin-Madison. Note: Materials may be edited for content and length.


Cite This Page:

University of Wisconsin-Madison. "Hormone-driven Effects On Eating, Stress Mediated By Same Brain Region." ScienceDaily. ScienceDaily, 29 September 2007. <www.sciencedaily.com/releases/2007/09/070926085136.htm>.
University of Wisconsin-Madison. (2007, September 29). Hormone-driven Effects On Eating, Stress Mediated By Same Brain Region. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2007/09/070926085136.htm
University of Wisconsin-Madison. "Hormone-driven Effects On Eating, Stress Mediated By Same Brain Region." ScienceDaily. www.sciencedaily.com/releases/2007/09/070926085136.htm (accessed July 22, 2014).

Share This




More Mind & Brain News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Do Obese Women Have 'Food Learning Impairment'?

Do Obese Women Have 'Food Learning Impairment'?

Newsy (July 18, 2014) Yale researchers tested 135 men and women, and it was only obese women who were deemed to have "impaired associative learning." Video provided by Newsy
Powered by NewsLook.com
Does Mixing Alcohol and Energy Drinks Boost Urge To Drink?

Does Mixing Alcohol and Energy Drinks Boost Urge To Drink?

Newsy (July 18, 2014) A new study suggests that mixing alcohol with energy drinks makes you want to keep the party going. Video provided by Newsy
Powered by NewsLook.com
Pot Cooking Class Teaches Responsible Eating

Pot Cooking Class Teaches Responsible Eating

AP (July 18, 2014) Following the nationwide trend of eased restrictions on marijuana use, pot edibles are growing in popularity. One Boston-area cooking class is teaching people how to eat pot responsibly. (July 18) Video provided by AP
Powered by NewsLook.com
Understanding D.C.'s New Pot Laws

Understanding D.C.'s New Pot Laws

Newsy (July 17, 2014) Washington D.C.'s new laws decriminalizing small amount of marijuana went into effect Thursday. Here's how they work. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins