Featured Research

from universities, journals, and other organizations

Ultrasound Plus Mammography Finds More Cancers, But Increases False Positives

Date:
October 3, 2007
Source:
University of North Carolina at Chapel Hill
Summary:
Adding ultrasound to mammography finds more cancers than mammography alone, but also substantially increases the number of false positives, according to first-year results from a three-year study of the two tests. The two tests combined will find approximately an additional one to seven cancers per 1,000 high-risk women who had not previously been screened by ultrasound.

Adding ultrasound to mammography finds more cancers than mammography alone, but also substantially increases the number of false positives, according to first-year results from a three-year study of the two tests.

"At this point, it's not clear whether the benefit provided by ultrasound outweighs the additional expense, stress and inconvenience caused by the false positives," said study co-author Etta Pisano, M.D., vice dean for academic affairs in the University of North Carolina at Chapel Hill School of Medicine, Kenan professor of radiology and biomedical engineering and director of the UNC Biomedical Research Imaging Center.

"We know that ultrasound does find more cancers. The question is, does it find enough more cancers to make it worthwhile?" she said.

The study's principal investigator and lead author is Wendie A. Berg, M.D., Ph.D., of American Radiology Services, located at Johns Hopkins at Greenspring Station in Lutherville, Md. UNC Hospitals is one of the primary study sites, with an enrollment of 198 women (7.5 percent of the study participants).

In the study, 2,637 women at high risk for breast cancer received both mammography and ultrasound exams. The tests were performed by physicians who received special training in breast ultrasound screening. Among the participants, 41 breast cancers were found in 40 women (one had cancer in both breasts) by one or both of the tests. Twelve of the cancers were found by ultrasound alone.

The addition of ultrasound resulted in 136 (5.2 percent) women having biopsies due to suspicion of cancer. Of these women, 14 or 8.5 percent were diagnosed with breast cancer.

Based on these results, the authors concluded that adding ultrasound to mammography will find approximately an additional one to seven cancers per 1,000 high-risk women who had not previously been screened by ultrasound, but will also substantially increase the number of false positives.

"We had hoped to see a bigger effect of ultrasound compared to mammography," Pisano said. "But I think these results show it's a mixed picture at this point."

Pisano said that the study will add magnetic resonance imaging (MRI) exams in its third year, allowing researchers to directly compare the effectiveness of MRI, ultrasound and mammography.

"At that point we will have good data on the cost-effectiveness of MRI versus ultrasound on top of mammography," she said. "That will be the definitive analysis."

The results were presented today (Sept. 28) at the American College of Radiology's fall meeting in Washington, D.C.

A previous study, for which Pisano was also a co-author, concluded that women with a recent diagnosis of cancer in one breast should have MRI screening of the opposite breast. The results of that study were published in the March 29, 2007, issue of the New England Journal of Medicine.

Pisano served as UNC's principal investigator in both studies. She also serves as chair of the Breast Committee for the American College of Radiology Imaging Network, the National Cancer Institute-sponsored cooperative group that sponsored the current study. Additional funding was provided by the Avon Foundation.


Story Source:

The above story is based on materials provided by University of North Carolina at Chapel Hill. Note: Materials may be edited for content and length.


Cite This Page:

University of North Carolina at Chapel Hill. "Ultrasound Plus Mammography Finds More Cancers, But Increases False Positives." ScienceDaily. ScienceDaily, 3 October 2007. <www.sciencedaily.com/releases/2007/09/070928160811.htm>.
University of North Carolina at Chapel Hill. (2007, October 3). Ultrasound Plus Mammography Finds More Cancers, But Increases False Positives. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2007/09/070928160811.htm
University of North Carolina at Chapel Hill. "Ultrasound Plus Mammography Finds More Cancers, But Increases False Positives." ScienceDaily. www.sciencedaily.com/releases/2007/09/070928160811.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins