Featured Research

from universities, journals, and other organizations

Trial Seeks 'Genetic Fingerprint' For Predicting Drug Effectiveness

Date:
October 8, 2007
Source:
University of Cincinnati
Summary:
Physician-scientists believe identifying a genetic "fingerprint" could help predict which specific therapies will be most effective for patients with gastric cancer. This trial addresses what the researcher calls the “future of cancer therapy”: targeted drug regimens, based on the characteristics of a patient’s specific tumor.

Syed Ahmad, MD, is a surgical oncologist at UC.
Credit: University of Cincinnati Department of Surgery

University of Cincinnati (UC) physician-scientists believe identifying a genetic “fingerprint” could help predict which specific therapies will be most effective for patients with gastric cancer.

Syed Ahmad, MD, is leading a national, phase-2 trial to test the effectiveness of combined chemotherapy and radiation therapy given to patients with gastric cancer before surgery. His team will also collect biological samples in an attempt to obtain genetic data that could be used to formulate targeted therapies.

Previous studies have established that either chemotherapy or radiation therapy after surgery can improve patient survival compared with surgery alone. Overall survival rates, however, remain low—with 20 to 30 percent of American patients surviving more than five years after treatment.

“Everyone agrees that without surgery, gastric cancer in not curable, and numerous studies have shown a benefit to follow-­up therapy with either chemotherapy or radiation therapy,” says Ahmad, assistant professor of surgery at UC and principal investigator of the trial.

“The problem is you can’t give both radiation therapy and chemotherapy after surgery—it’s too toxic and patients can’t tolerate it,” he says. “But you can give it before surgery when patients are healthiest.”

This trial addresses what Ahmad calls the “future of cancer therapy”: targeted drug regimens, based on the characteristics of a patient’s specific tumor.

His goal is to identify a genetic “fingerprint” that could help predict whether patients will respond to therapy, and then identify drugs to address the specific molecular characteristics of that patient’s tumor.

“Right now treatment is based on the assumption that site-based cancers are all the same, so every patient who has stage-3 gastric cancer will get the same chemotherapy drugs,” Ahmad explains. “But the reality is that every cancer has a different expression of hormones, growth factors and genetic factors that must be addressed individually."

The UC-led national team is looking for about 70 patients across the United States with up to stage-3 gastric cancer to participate in the trial.

Prior to surgery, all study participants will have a biopsy to set baseline standards for genetic testing to determine which patients have a complete response to the multi-treatment therapy. Participants will receive daily doses of the platinum-containing drug oxaliplatin (ox-AL’-ih-plah-tin, marketed as Eloxatin) for six to eight weeks.

Approved by the Food and Drug Administration, oxaliplatin is currently used to treat advanced colorectal cancer. Studies have shown the drug has fewer toxicity complications compared with other therapies.

After six weeks of chemotherapy, the patient will get five consecutive days of three-dimensional, external-beam radiation therapy. Patients will be reevaluated two to three weeks after radiation to determine if they are eligible for surgery. Those who are suitable will have another tissue biopsy after surgery.

Researchers will compare pre- and post-surgery tissue samples to obtain the genetic data necessary to establish associations between molecular markers and drug resistance, with the goal of reducing toxicity associated with chemotherapeutic agents and improving patient survival.

For more information on enrollment in this trial, sponsored by the Southwest Oncology Group, call the UC cancer clinical trials office at (513) 584-7698.


Story Source:

The above story is based on materials provided by University of Cincinnati. Note: Materials may be edited for content and length.


Cite This Page:

University of Cincinnati. "Trial Seeks 'Genetic Fingerprint' For Predicting Drug Effectiveness." ScienceDaily. ScienceDaily, 8 October 2007. <www.sciencedaily.com/releases/2007/10/071003130837.htm>.
University of Cincinnati. (2007, October 8). Trial Seeks 'Genetic Fingerprint' For Predicting Drug Effectiveness. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2007/10/071003130837.htm
University of Cincinnati. "Trial Seeks 'Genetic Fingerprint' For Predicting Drug Effectiveness." ScienceDaily. www.sciencedaily.com/releases/2007/10/071003130837.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) — Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) — Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) — A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) — The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins