Featured Research

from universities, journals, and other organizations

Double Cardiovascular Benefit For People With Chronic Kidney Disease

Date:
October 5, 2007
Source:
The George Institute
Summary:
Scientists have found that lowering blood pressure protects stroke victims with chronic kidney disease from further strokes or heart attacks. Given the high risk of cardiovascular complications in people with chronic kidney disease, these results have significant implications for millions of people across the world.

New research by The George Institute for International Health in Sydney, has found that lowering blood pressure protects stroke victims with Chronic Kidney Disease from further strokes or heart attacks. Given the high risk of cardiovascular complications in people with Chronic Kidney Disease (CKD), these results have significant implications for millions of people across the world.

According to lead author, Dr Vlado Perkovic at The George Institute, most of the CKD population will die from cardiovascular complications. "People with Chronic Kidney Disease are at a significantly greater risk of cardiovascular events than those without the disease. We found that approximately twice as many cardiovascular events were prevented when a perindopril based blood pressure lowering regimen was used in these people, compared to people with normal kidney function."

The findings are based on a unique data set of around 1,800 patients who were part of a large clinical trial conducted on blood pressure and stroke, called PROGRESS. Dr Perkovic added that "The findings from PROGRESS have shifted the focus away from treating individuals with high blood pressure to focusing on those people at particularly high risk of heart disease and stroke. This research suggests that kidney function is an important parameter to consider in identifying these high risk individuals."

Chronic Kidney Disease (CKD) affects approximately one in six adults in Western Countries, and this proportion increases rapidly with increasing age. Over the last 25 years, while the Australian population has grown less than 40%, the number of Australians being treated with dialysis or a kidney transplant has grown more than 400%. Data from the Australian Bureau of statistics collected between 1997 and 1999 shows that approximately one in 10 death certificates listed kidney disease as the underlying or as an associated cause of death. The true contribution of kidney disease to premature mortality is likely to be significantly higher*.

Australia's annual spending on end stage kidney disease (ESKD) is $750 million, which is increasing by $50 million each year. This is just a small proportion of the total costs associated with kidney disease in this country.

PROGRESS was completed in 2001 and had a direct clinical impact for more than 50 million individuals with cerebrovascular disease worldwide. Results showed that blood pressure lowering reduced the risk of stroke by a quarter among patients with a history of cerebrovascular disease. Many further papers documenting the effects of treatment on other important outcomes, such as preventing heart attacks and the development of dementia, have now been published.

This research was published October 5 in the Journal of American Society of Nephrology.

Funding was provided by grants supplied by Servier, the Health Research Council of New Zealand, and the National Health and Medical Research Council of Australia.


Story Source:

The above story is based on materials provided by The George Institute. Note: Materials may be edited for content and length.


Cite This Page:

The George Institute. "Double Cardiovascular Benefit For People With Chronic Kidney Disease." ScienceDaily. ScienceDaily, 5 October 2007. <www.sciencedaily.com/releases/2007/10/071005092733.htm>.
The George Institute. (2007, October 5). Double Cardiovascular Benefit For People With Chronic Kidney Disease. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2007/10/071005092733.htm
The George Institute. "Double Cardiovascular Benefit For People With Chronic Kidney Disease." ScienceDaily. www.sciencedaily.com/releases/2007/10/071005092733.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Reasons Why Teen Birth Rates Are At An All-Time Low

Reasons Why Teen Birth Rates Are At An All-Time Low

Newsy (Aug. 20, 2014) A CDC report says birth rates among teenagers have been declining for decades, reaching a new low in 2013. We look at several popular explanations. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins