Featured Research

from universities, journals, and other organizations

Alzheimer's Disease: Injectable Antibody May Attack Source Of Problem

Date:
October 8, 2007
Source:
Saint Louis University
Summary:
Researchers have found that an antibody can reverse learning problems in an animal model of Alzheimer's disease. The protein is an antibody that grabs onto the amyloid beta protein in the brain and prevents it from changing into the toxic substance believed to cause Alzheimer's disease.

A special protein can be injected into the body to reverse learning problems in mice that have an animal version of Alzheimer's disease, Saint Louis University researchers have found.

The protein -- part of the immunoglobulin M (IgM) class -- is an antibody that grabs onto the amyloid beta protein in the brain and prevents it from changing into the toxic substance believed to cause Alzheimer's disease.

"Our research in an animal model showed that antibodies can be developed rationally for treating Alzheimer's disease," says William A. Banks, M.D. professor of geriatrics and pharmacological and physiological science at Saint Louis University. "It's a major thing that people have been trying to do -- get antibodies into the brain in the right amount to treat illnesses. This antibody does that."

Banks says the findings are surprising because IgM is five times bigger than the antibody immunoglobulin G (IgG), which has already been studied as a potential therapy for Alzheimer's disease.

Because it is larger, scientists didn't believe it could cross the blood- brain barrier, a protective membrane that keeps foreign substances out of the brain.

"We collaborated with Michael Steinitz from Hebrew University in Jerusalem, who developed an antibody that is part of the IgM class of antibodies that would stick better to amyloid beta protein," says Banks, who also is a staff physician at Veterans Affairs Medical Center in St. Louis Banks says.

"This compound had better entry to the brain than IgG, even though they are smaller."

A single intravenous dose of IgM reversed cognitive impairment in aged mice that have a genetic mutation that causes deficits similar to those found in patients with Alzheimer's disease, Banks says.

The findings were published in the August issue of Experimental Neurology.


Story Source:

The above story is based on materials provided by Saint Louis University. Note: Materials may be edited for content and length.


Cite This Page:

Saint Louis University. "Alzheimer's Disease: Injectable Antibody May Attack Source Of Problem." ScienceDaily. ScienceDaily, 8 October 2007. <www.sciencedaily.com/releases/2007/10/071008094837.htm>.
Saint Louis University. (2007, October 8). Alzheimer's Disease: Injectable Antibody May Attack Source Of Problem. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2007/10/071008094837.htm
Saint Louis University. "Alzheimer's Disease: Injectable Antibody May Attack Source Of Problem." ScienceDaily. www.sciencedaily.com/releases/2007/10/071008094837.htm (accessed April 16, 2014).

Share This



More Health & Medicine News

Wednesday, April 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com
Cognitive Function: Is It All Downhill From Age 24?

Cognitive Function: Is It All Downhill From Age 24?

Newsy (Apr. 15, 2014) A new study out of Canada says cognitive motor performance begins deteriorating around age 24. Video provided by Newsy
Powered by NewsLook.com
How Mt. Everest Helped Scientists Research Diabetes

How Mt. Everest Helped Scientists Research Diabetes

Newsy (Apr. 15, 2014) British researchers were able to use Mount Everest's low altitudes to study insulin resistance. They hope to find ways to treat diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins