Featured Research

from universities, journals, and other organizations

Mesalamine Linked To Cancer Protection For High Risk Inflammatory Bowel Disease Patients

Date:
October 15, 2007
Source:
American College of Gastroenterology
Summary:
Mesalamine use among patients with inflammatory bowel disease was associated with a decrease in incidence of colorectal cancer when comparing cases and controls. Patients with IBD are at significantly higher than average risk for colorectal cancer and should be screened more frequently, but another study revealed many don't get recommended tests.

Researchers found that mesalamine use among patients with inflammatory bowel disease was associated with a decrease in incidence of colorectal cancer when comparing cases and controls. In the study presented at the 72nd Annual Scientific Meeting of the American College of Gastroenterology, researchers from Henry Ford Hospital in Detroit matched 16 patients with ulcerative colitis and Crohn's disease to 23 controls with similar body mass index, family history of IBD, family history of colorectal cancer and smoking.

Related Articles


Among those with ulcerative colitis who did not get colorectal cancer, researchers found that 100 percent used mesalamine. While among those with UC who developed colorectal cancer only 76.9 percent used mesalamine. "This finding suggests an association between mesalamine use and reduced risk of colorectal cancer," according to Jeffrey Tang, M.D. Dr. Tang and his colleagues, including Ann L. Silverman, M.D., conducted conditional logistic regression analysis which revealed that at doses greater than 5068 grams mesalamine use in patients with IBD was associated with an 89 percent reduction in risk of colorectal cancer, compared to IBD patients matched for other major risk factors. While these are provocative findings, it should be noted that this is a small study and further investigation is needed on the chemoprevention potential of mesalamine.

Patients with inflammatory bowel disease including ulcerative colitis and Crohn's disease are at significantly higher than average risk for colorectal cancer and should be screened for colorectal cancer according to accepted guidelines, which recommend more frequent screening among those with IBD. However, some research suggests this is not happening.

Poor Adherence to Recommended Screenings for Colorectal Cancer Among IBD Patients

In another study conducted at the University of California, San Francisco and Kaiser Permanente of Northern California and presented at the ACG Annual Meeting, researchers looked at rates of participation in colorectal cancer screening by patients with IBD in an integrated health system with access to colonoscopy. An intensive program of colonoscopic screening and surveillance is recommended to prevent colorectal cancer in patients with ulcerative colitis, who are at higher than average risk.

In this study of 358 patients with ulcerative colitis who were eligible for screening, only one third were screened once during the period 2001 to 2005. Of these 123 patients, only 52 percent had an additional surveillance colonoscopy within the recommended period of one to two years. Overall, only 18 percent of the eligible patients at high risk for colorectal cancer due to history of ulcerative colitis adhered to recommended surveillance guidelines.


Story Source:

The above story is based on materials provided by American College of Gastroenterology. Note: Materials may be edited for content and length.


Cite This Page:

American College of Gastroenterology. "Mesalamine Linked To Cancer Protection For High Risk Inflammatory Bowel Disease Patients." ScienceDaily. ScienceDaily, 15 October 2007. <www.sciencedaily.com/releases/2007/10/071015081459.htm>.
American College of Gastroenterology. (2007, October 15). Mesalamine Linked To Cancer Protection For High Risk Inflammatory Bowel Disease Patients. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2007/10/071015081459.htm
American College of Gastroenterology. "Mesalamine Linked To Cancer Protection For High Risk Inflammatory Bowel Disease Patients." ScienceDaily. www.sciencedaily.com/releases/2007/10/071015081459.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
WHO Says Male Ebola Survivors Should Abstain From Sex

WHO Says Male Ebola Survivors Should Abstain From Sex

Newsy (Nov. 28, 2014) — WHO cites four studies that say Ebola can still be detected in semen up to 82 days after the onset of symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins