Featured Research

from universities, journals, and other organizations

Genetic Influence On Pace Of HIV-AIDS Progression Identified

Date:
October 24, 2007
Source:
NIH/National Institute of Allergy and Infectious Diseases
Summary:
Viral load -- the amount of virus in the blood of an HIV-infected person -- has long been viewed as the chief indicator of how quickly someone infected with HIV infection progresses to AIDS. New data builds on previous work that suggests that several other factors in addition to viral load significantly contribute to disease progression rates.

Viral load--the amount of virus in the blood of an HIV-infected person--has long been viewed as the chief indicator of how quickly someone infected with HIV infection progresses to AIDS.

New data published in Nature Immunology builds on previous work that suggests that several other factors in addition to viral load significantly contribute to disease progression rates.

Researchers led by Sunil Ahuja, M.D., of the University of Texas Health Science Center in San Antonio, examined genetic information from more than 3,500 HIV-1 infected and uninfected individuals.

They found that individuals who had specific combinations of two genes--CCR5, which helps facilitate HIV entry into the cell, and CCL3L1, an immune response gene--were much more likely to have reduced immune responses and a greater decline in CD4 T cells, two hallmarks of progressive HIV disease.

Further, the researchers found that in HIV-infected subjects, viral load contributed only 9 percent to the variability in rate of progression to AIDS; variations in CCR5 and CCL3L1 combined accounted for 6 percent variability in AIDS progression rates.

The findings may have implications for the care of HIV-infected individuals in terms of being able to more effectively predict the course of HIV disease. With further research, this work may lead to additional markers, which along with viral load may serve as indicators of HIV progression. The study was funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

Article: "CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms" by Matthew J. Dolan et al. Nature Immunology (Published online Sunday, October 21, 2007). DOI: 10.1038/ni1521 (2007).


Story Source:

The above story is based on materials provided by NIH/National Institute of Allergy and Infectious Diseases. Note: Materials may be edited for content and length.


Cite This Page:

NIH/National Institute of Allergy and Infectious Diseases. "Genetic Influence On Pace Of HIV-AIDS Progression Identified." ScienceDaily. ScienceDaily, 24 October 2007. <www.sciencedaily.com/releases/2007/10/071022122210.htm>.
NIH/National Institute of Allergy and Infectious Diseases. (2007, October 24). Genetic Influence On Pace Of HIV-AIDS Progression Identified. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2007/10/071022122210.htm
NIH/National Institute of Allergy and Infectious Diseases. "Genetic Influence On Pace Of HIV-AIDS Progression Identified." ScienceDaily. www.sciencedaily.com/releases/2007/10/071022122210.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins