Featured Research

from universities, journals, and other organizations

Vitamin A Derivative Associated With Reduced Growth In Some Lung Cells

Date:
October 31, 2007
Source:
Journal of the National Cancer Institute
Summary:
Treatment with a derivative of vitamin A called retinoic acid was associated with reduced lung cell growth in a group of former heavy smokers, according to a new study. Former smokers remain at elevated risk for lung cancer.

Treatment with a derivative of vitamin A called retinoic acid was associated with reduced lung cell growth in a group of former heavy smokers, according to a study published in the Journal of the National Cancer Institute.

Former smokers remain at elevated risk for lung cancer. According to one hypothesis, lung cells that were damaged during years of smoking may continue to grow and evolve into cancer even after that person has quit smoking. Previous studies have suggested that retinoids, a class of drugs related to vitamin A, may be effective for preventing lung cancer in former smokers. Retinoids have also been shown to slow the growth of cancer cells in laboratory experiments.

Investigators at the University of Texas M.D. Anderson Cancer Center in Houston previously conducted a double-blind lung cancer prevention trial among 225 former heavy smokers. The subjects were randomly assigned to receive a 3-month treatment of 13-cis-retinoic acid and vitamin E, or 9-cis-retinoic acid, or a placebo. Walter Hittelman, Ph.D., and colleagues later examined biopsy samples of participants' lung tissue taken before and after treatment, then measured the proliferation of the cells using a biomarker called Ki-67.

Both treatments reduced cell proliferation in one layer of the lung cells (the parabasal layer), but not the other (the basal layer), which surprised the researchers.

In patients given 13-cis-retinoic acid and vitamin E, there was a statistically significant reduction in parabasal layer cell growth compared with the placebo treatment, but not in those given 9-cis-retinoic acid. When the data were analyzed by the biopsy site, both treatments statistically significantly reduced cell growth.

"It will therefore be important to distinguish the effects of molecularly targeted agents on the basal and parabasal [lung cell] layers in proposed lung chemoprevention trials with long follow-up," the authors write.

In an accompanying editorial, Eva Szabo, M.D., of the National Cancer Institute in Bethesda, Md., discusses the appropriateness of using the biomarker Ki-67 as an alternative endpoint in cancer prevention trials. While the biomarker showed that the retinoid agents were able to reduce cell growth, she says it is still too soon to test them in more advanced clinical trials. "We do not have a full understanding of the effects of these agents on [lung cells] or their effects during the full spectrum of carcinogenesis," she writes.

Journal article: Hittelman WN, Liu DD, Kurie JM, Lotan R, Lee JS, Khuri F, et al. Proliferative Changes in the Bronchial Epithelium of Former Smokers Treated With Retinoids. J Natl Cancer Inst 2007; 99:1603-1612

Editorial: Szabo E. Proliferative Changes in Chemoprevention Trials: Learning From Secondary Endpoints. J Natl Cancer Inst 2007; 99:1565-1567


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal of the National Cancer Institute. "Vitamin A Derivative Associated With Reduced Growth In Some Lung Cells." ScienceDaily. ScienceDaily, 31 October 2007. <www.sciencedaily.com/releases/2007/10/071030160943.htm>.
Journal of the National Cancer Institute. (2007, October 31). Vitamin A Derivative Associated With Reduced Growth In Some Lung Cells. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2007/10/071030160943.htm
Journal of the National Cancer Institute. "Vitamin A Derivative Associated With Reduced Growth In Some Lung Cells." ScienceDaily. www.sciencedaily.com/releases/2007/10/071030160943.htm (accessed September 1, 2014).

Share This




More Health & Medicine News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
New Drug Could Reduce Cardiovascular Deaths

New Drug Could Reduce Cardiovascular Deaths

Newsy (Aug. 30, 2014) The new drug from Novartis could reduce cardiovascular deaths by 20 percent compared to other similar drugs. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins