Featured Research

from universities, journals, and other organizations

Large Dose Dexamethasone Plays Important Roles In Severe Acute Pancreatitis

Date:
November 2, 2007
Source:
World Journal of Gastroenterology
Summary:
The sound therapeutic effects of large dose dexamethasone on severe acute pancreatitis have been demonstrated, but the mechanism of large dose dexamethasone treatment in SAP has not been explored. A research group demonstrated that potential mechanisms were related to the inflammatory mediators inhibition and pancreatic acinar cell apoptosis, based on the application of the tissue microarray technique.

Severe acute pancreatitis (SAP) is a fatal systemic disease featuring acute onset, serious conditions, high incidence of complications and 20 - 30% mortality, mainly due to multiple organ failure at its early stage. The pathogenesis of SAP is closely related to factors such as activation of pancreatin, release of inflammatory mediators, microcirculation disturbance and apoptosis.

However, excessive inflammatory mediators release was regarded as a vital role in the development of SAP. In recent years, it has been found that both inflammatory mediators and pancreatic acinar cell apoptosis are participants in the onset of SAP. The apoptosis of pancreatic acinar cells may be a reaction beneficial to the body after the occurrence of SAP.

The effect of glucocorticoid (represented by dexamethasone) on AP/SAP has been an issue in dispute. In 1952, Stephensen for the first time reported the effect of glucocorticoid in AP treatment. Many empirical studies show glucocorticoid can improve the survival of AP animals. Its mechanisms mainly are: inhibiting the generation of inflammatory mediators and/or inhibiting the effects of inflammatory mediators, enhancing body stress, improving microcirculation, alleviating endotoxemia, cleaning free radicals, inhibiting nitric oxide (NO) and expression of NF- kappa B. In terms of administration and dose, many studies also found a large dose of dexamethasone was obviously superior to the small dose dexamethasone in therapeutic effect, and early use of dexamethasone was superior to dexamethasone of the same dose.

The research team, led by Dr. Zhang Xi-Ping from the First People‘―s Hospital of Hangzhou and 2nd Affiliated Hospital of Zhejiang University, found that the large dose dexamethasone treatment rats‘― survival rate, ascites/body weight ratio, plasma amylase and endotoxin content and inflammatory mediators (such as TNF-¦Α and IL-6) were lower than in SAP rats. With the application of tissue microarray technique, it was shown that pathological change of pancreatic tissue and its severity scores were also greatly alleviated with large dose dexamethasone treatment. Compared with the SAP rats, the pancreatic acinar cell apoptosis was induced and the apoptotic index was significantly promoted with the large dose dexamethasone treatment.

The article clarified that large dose dexamethasone therapeutic mechanisms in SAP may be related to the inhibition of inflammatory mediators and the induction of pancreatic acinar cell apoptosis, demonstrated by the application of tissue microarray technique.

Reference: Zhang XP, Chen L, Hu QF, Tian H, Xu RJ, Wang ZW, Wang KY, Cheng QH, Yan W, Li Y, Li QY, He Q, Wang F.Effects of large dose of dexamethasone on inflammatory mediators and pancreatic cell apoptosis of rats with severe acute pancreatitis. World J Gastroenterol 2007; 13(41): 5506-5511 


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Cite This Page:

World Journal of Gastroenterology. "Large Dose Dexamethasone Plays Important Roles In Severe Acute Pancreatitis." ScienceDaily. ScienceDaily, 2 November 2007. <www.sciencedaily.com/releases/2007/11/071102094415.htm>.
World Journal of Gastroenterology. (2007, November 2). Large Dose Dexamethasone Plays Important Roles In Severe Acute Pancreatitis. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2007/11/071102094415.htm
World Journal of Gastroenterology. "Large Dose Dexamethasone Plays Important Roles In Severe Acute Pancreatitis." ScienceDaily. www.sciencedaily.com/releases/2007/11/071102094415.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) — Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) — Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) — Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) — Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins