Featured Research

from universities, journals, and other organizations

Therapy Reduces Risk Of Heart Attack By 80% In People With Rheumatoid Arthritis, Study Shows

Date:
November 13, 2007
Source:
American College of Rheumatology
Summary:
Rheumatoid arthritis is a chronic disease that causes pain, stiffness, swelling, and limitation in the motion and function of many joints. An estimated 2.1 million Americans have RA, most of them women. Although joints are the principal body parts affected by RA, inflammation can develop in other organs as well. Heart attacks, resulting from inflammation of the coronary vessels, are more common in RA sufferers.

The use of combination TNF-inhibitor-methotrexate therapy in people with rheumatoid arthritis was associated with a risk of heart attack that was reduced by 80 percent in comparison with those using methotrexate alone, according to research presented recently at the American College of Rheumatology Annual Scientific Meeting in Boston, Mass.

Rheumatoid arthritis is a chronic disease that causes pain, stiffness, swelling, and limitation in the motion and function of many joints. An estimated 2.1 million Americans have RA, most of them women. Although joints are the principal body parts affected by RA, inflammation can develop in other organs as well. Heart attacks, resulting from inflammation of the coronary vessels, are more common in RA sufferers.

Researchers recently studied the risk of heart attack in patients using a TNF-inhibitor (a drug that blocks cytokines and can reduce pain, morning stiffness and swollen joints in RA), methotrexate (a drug used to treat RA by blocking the metabolism of cells) and other DMARDs (a category of drugs used in many autoimmune disorders to slow down the disease progression) in a large population of patients with RA—many of whom were also taking aspirin.

Using data obtained from MediCal, California’s Medicaid program, researchers studied patients over the age of 18, suffering from RA, who were treated with TNF-inhibitors, methotrexate, or other DMARDs, over six-and-a-half years.

A total of 19,233 patients with RA were identified. The patients’ mean age was 55 years, and approximately 79 percent were women. Of these patients, 13,383 took methotrexate; 14,958 took other DMARDS; and 4,943 took TNF-inhibitors. Exposure to TNF-inhibitors (taken alone or in combination with methotrexate) was compared to taking methotrexate alone.

During the study period, 441 patients suffered heart attacks, of which eight percent were fatal.

Researchers found that patients on a combination of TNF-inhibitors with methotrexate treatment had a heart attack risk of only 20 percent of the risk compared to patients taking methotrexate alone.

However, there was no statistical difference seen among patients who were taking TNF-inhibitors alone, TNF-inhibitors with other DMARDs, other DMARD therapies without methotrexate, or a combination of DMARDs and methotrexate.

“TNF-inhibitor therapy, in combination with methotrexate, dramatically reduces the risk of heart attacks in patients with RA and should be seriously considered— especially in high-risk patients,” said Gurkirpal Singh, MD; adjunct clinical professor of medicine, division of gastroenterology and hepatology, Stanford University School of Medicine; chief science officer, Institute of Clinical Outcomes Research and Education; and an investigator in the study.


Story Source:

The above story is based on materials provided by American College of Rheumatology. Note: Materials may be edited for content and length.


Cite This Page:

American College of Rheumatology. "Therapy Reduces Risk Of Heart Attack By 80% In People With Rheumatoid Arthritis, Study Shows." ScienceDaily. ScienceDaily, 13 November 2007. <www.sciencedaily.com/releases/2007/11/071109203953.htm>.
American College of Rheumatology. (2007, November 13). Therapy Reduces Risk Of Heart Attack By 80% In People With Rheumatoid Arthritis, Study Shows. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2007/11/071109203953.htm
American College of Rheumatology. "Therapy Reduces Risk Of Heart Attack By 80% In People With Rheumatoid Arthritis, Study Shows." ScienceDaily. www.sciencedaily.com/releases/2007/11/071109203953.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins