Featured Research

from universities, journals, and other organizations

Drug May Limit Radiation Kidney Damage In Bone Marrow Transplantation Patients

Date:
November 19, 2007
Source:
Medical College of Wisconsin
Summary:
Researchers have found that the risk of radiation injury in normal tissue after exposure may be reduced by a drug in common use. It suggests that long-term administration of the drug captopril, starting at three weeks after patients receive total body irradiation in preparation for bone marrow transplantation (BMT), showed a favorable trend for better long-term kidney function and better long-term patient survival.

Researchers at the Medical College of Wisconsin in Milwaukee have found that the risk of radiation injury in normal tissue after exposure may be reduced by a drug in common use.

Related Articles


It suggests that long-term administration of the drug captopril, starting at three weeks after patients receive total body irradiation in preparation for bone marrow transplantation (BMT), showed a favorable trend for better long-term kidney function and better long-term patient survival. Chronic kidney failure continues to be a major complication in these patients caused by radiation injury.

"The research holds promise, not only for protection of healthy tissue during radiation therapy, but also because it may lead to strategies for protection from radiation injury after nuclear accidents," says Eric P. Cohen, M.D., professor of medicine in the division of nephrology, and principal investigator for the study. "Our findings overturned the former dogma that normal tissue radiation injury is untreatable," he says.

Kidney failure is a well known and serious complication of BMT and occurs in up to 50 percent of patients within the first 30 days after transplantation, increasing early mortality. Chronic kidney failure is also common and affects the health and well being of people otherwise cured of the cancer for which the BMT was performed.

In a double-blind placebo-controlled trial, the team tested captopril on 52 adults and three children undergoing bone marrow transplant from July 1998 to January 2006 at Froedtert Hospital and Children's Hospital of Wisconsin, both major teaching affiliates of the College. When compared to a placebo, captopril-treated subjects had better kidney function and better patient survival.

"The statistics do not show a definite significant value, but the trends are there," Dr. Cohen says.

Captopril is an angiotensin-converting enzyme (ACE) inhibitor; a class of drugs that help relax blood vessels, and is currently approved by the U.S. Food and Drug Administration for treatment of hypertension, heart failure, and diabetic nephropathy. Because Captopril may cause leukopenia, the study drug was not started until the new marrow had engrafted in the participants. Leukopenia is a condition in which the white blood cells fall below normal.

"The three-week delay in administration of the drug was justified by our animal studies in the late 1990s which showed that a delayed start of captopril could successfully prevent radiation injury to the kidney," Says Dr. Cohen.

"In an earlier 1992 animal study, published in Radiation Research, we found that captopril was effective in treating chronic kidney damage and its progression after total body irradiation. That showed that normal tissue radiation injury can be treated," he says.

Their study in press appears in the on line issue of the International Journal of Radiation Oncology, Biology and Physics.

Dr. Cohen's faculty colleagues on the team include, co-investigator John E. Moulder, Ph.D., professor of radiation oncology; William R. Drobyski, M.D., professor of medicine; Jakob Passweg, M.D., then research associate, now chair of hematology, University of Geneva; and Mark B. Juckett, M.D., associate professor, in the division of neoplastic diseases and related disorders; Amy A. Irving, B.A., research technologist in radiation oncology; John P. Klein, Ph.D., professor of population health and director of biostatistics, and Julie-An M. Talano, M.D., assistant professor of pediatrics.

The study was funded by the National Institutes of Health's National Cancer Institute, and by a grant from the American Cancer Society.


Story Source:

The above story is based on materials provided by Medical College of Wisconsin. Note: Materials may be edited for content and length.


Cite This Page:

Medical College of Wisconsin. "Drug May Limit Radiation Kidney Damage In Bone Marrow Transplantation Patients." ScienceDaily. ScienceDaily, 19 November 2007. <www.sciencedaily.com/releases/2007/11/071114162739.htm>.
Medical College of Wisconsin. (2007, November 19). Drug May Limit Radiation Kidney Damage In Bone Marrow Transplantation Patients. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2007/11/071114162739.htm
Medical College of Wisconsin. "Drug May Limit Radiation Kidney Damage In Bone Marrow Transplantation Patients." ScienceDaily. www.sciencedaily.com/releases/2007/11/071114162739.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins