Featured Research

from universities, journals, and other organizations

New Discoveries About Nitric Oxide Can Provide Drugs For Schizophrenia

Date:
November 23, 2007
Source:
Göteborg University
Summary:
Problems with memory and social function in patients with schizophrenia may result from an imbalance in the brain's nitric oxide system. A new dissertation shows that rats with characteristics of schizophrenia regain normal brain function if they receive drugs that reduce the production of nitric oxide in the brain.

Problems with memory and social function in patients with schizophrenia may result from an imbalance in the brain’s nitric oxide system. A dissertation from the Sahlgrenska Academy at Göteborg University in Sweden shows that rats with characteristics of schizophrenia regain normal brain function if they receive drugs that reduce the production of nitric oxide in the brain.

Related Articles


Schizophrenia is a serious and common disease that can cause hallucinations, delusions and apathy. Problems with memory, social cognition and other intellectual abilities are also common.

"Schizophrenic patients can be treated with anti-psychotic drugs, but the treatment does not help cognitive disturbances or impaired social function to any appreciable degree. We believe that this is due to an imbalance in the brain’s nitric oxide system, and if this is the case, we may be able to develop a completely new type of treatment," says pharmacologist Caroline Wass.

In these studies, rate and mice were given a drug called phencyclidine. This substance causes a schizophrenia-like state in humans.

"Rats and mice don’t become schizophrenic, but the drug has a similar effect on thought processes in rodents to the effect it has in humans," says Caroline Wass.

The animals’ learning capacity, memory and social interaction were measured using several different behaviour models. When the animals were treated with a substance that blocks brain nitric oxide production, they became resistant to the schizophrenia-like effects of phencyclidine.

The research team will shortly initiate a patient study in order to find out whether blocking brain nitric oxide production can alleviate cognitive disturbances in patients with schizophrenia.

"In the future it is possible that drugs that affect the regulation of nitric oxide in the brain can be used to supplement currently existing anti-psychotic agents. The hope is that nitric oxide inhibiting drugs will alleviate the cognitive disturbances that also lie behind the impairments of social function, significantly improving the chances of a good life for schizophrenic patients," says Caroline Wass.

Schizophrenia facts

Schizophrenia is a psychiatric illness that affects 1% of the population. There is no cure, but the psychotic symptoms can be treated with psychotropic drugs. The illness often first appears in the twenties. It is usually chronic, and most sufferers never return to work or to full-time education.

This research is a dissertation for research doctorate in medicine from the Sahlgrenska Academy, Institute of Neuroscience and Physiology.

The title of the dissertation is "Cognition and social behaviour in schizophrenia: An animal model investigating the potential role of nitric oxide."


Story Source:

The above story is based on materials provided by Göteborg University. Note: Materials may be edited for content and length.


Cite This Page:

Göteborg University. "New Discoveries About Nitric Oxide Can Provide Drugs For Schizophrenia." ScienceDaily. ScienceDaily, 23 November 2007. <www.sciencedaily.com/releases/2007/11/071121213845.htm>.
Göteborg University. (2007, November 23). New Discoveries About Nitric Oxide Can Provide Drugs For Schizophrenia. ScienceDaily. Retrieved January 26, 2015 from www.sciencedaily.com/releases/2007/11/071121213845.htm
Göteborg University. "New Discoveries About Nitric Oxide Can Provide Drugs For Schizophrenia." ScienceDaily. www.sciencedaily.com/releases/2007/11/071121213845.htm (accessed January 26, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Monday, January 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Technology Is Ruining Snow Days For Students

How Technology Is Ruining Snow Days For Students

Newsy (Jan. 25, 2015) — More schools are using online classes to keep from losing time to snow days, but it only works if students have Internet access at home. Video provided by Newsy
Powered by NewsLook.com
Weird Things Couples Do When They Lose Their Phone

Weird Things Couples Do When They Lose Their Phone

BuzzFeed (Jan. 24, 2015) — Did you back it up? Do you even know how to do that? Video provided by BuzzFeed
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) — A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com
Amazing Technology Allows Blind Mother to See Her Newborn Son

Amazing Technology Allows Blind Mother to See Her Newborn Son

RightThisMinute (Jan. 23, 2015) — Not only is Kathy seeing her newborn son for the first time, but this is actually the first time she has ever seen a baby. Kathy and her sister, Yvonne, have been legally blind since childhood, but thanks to an amazing new technology, eSight glasses, which gives those who are legally blind the ability to see, she got the chance to see the birth of her son. It&apos;s an incredible moment and an even better story. Video provided by RightThisMinute
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins