Featured Research

from universities, journals, and other organizations

Breast Cancer Risk Elevated In Male BRCA Mutation Carriers

Date:
November 29, 2007
Source:
Journal of the National Cancer Institute
Summary:
Men with mutations in the BRCA1 or BRCA2 genes are at greater risk of breast cancer than the general population. Male breast cancer accounts for less than 1 percent of all breast cancers in the U.S., and it is most common in men with a family history of the disease. Previous studies have shown that men who carry mutations in the BRCA2 gene have a greater risk of developing breast cancer than men in the general population. The association between BRCA1 mutations and breast cancer in men was less clear.

Men with mutations in the BRCA1 or BRCA2 genes are at greater risk of breast cancer than the general population.

Related Articles


Male breast cancer accounts for less than 1 percent of all breast cancers in the U.S., and it is most common in men with a family history of the disease. Previous studies have shown that men who carry mutations in the BRCA2 gene have a greater risk of developing breast cancer than men in the general population.

The association between BRCA1 mutations and breast cancer in men was less clear.

Sining Chen, Ph.D., of Johns Hopkins University and colleagues analyzed data from the National Cancer Institute's Cancer Genetics Network on 1,939 families including 97 men with breast cancer.

The risk of developing breast cancer was higher in male BRCA1 and BRCA2 mutation carriers, compared with noncarriers, but BRCA2 mutation carriers had the highest risk. The relative risk was greatest for men in their 30s and 40s and decreased with age. The estimated breast cancer risk of a 70 year old male BRCA2 mutation carrier was 6.8 percent, compared with 1.2 percent for BRCA1 mutation carriers.

"Such risk estimates are important for determining appropriate risk management strategies for the male members of families with germline mutations in BRCA1 or BRCA2," the authors write.


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal of the National Cancer Institute. "Breast Cancer Risk Elevated In Male BRCA Mutation Carriers." ScienceDaily. ScienceDaily, 29 November 2007. <www.sciencedaily.com/releases/2007/11/071127171305.htm>.
Journal of the National Cancer Institute. (2007, November 29). Breast Cancer Risk Elevated In Male BRCA Mutation Carriers. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2007/11/071127171305.htm
Journal of the National Cancer Institute. "Breast Cancer Risk Elevated In Male BRCA Mutation Carriers." ScienceDaily. www.sciencedaily.com/releases/2007/11/071127171305.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins