Featured Research

from universities, journals, and other organizations

Antibacterial Chemical Disrupts Hormone Activities, Study Finds

Date:
December 8, 2007
Source:
University of California - Davis
Summary:
A new study shows that a common antibacterial chemical added to bath soaps is an endocrine disruptor that can alter hormonal activity in rats and in human cells in the laboratory -- and does so by a previously unreported mechanism. Called endocrine disruptors, or endocrine disrupting substances (EDS), such chemicals have been linked in animal studies to a variety of problems, including cancer, reproductive failure and developmental anomalies.

A new UC Davis study shows that a common antibacterial chemical added to bath soaps can alter hormonal activity in rats and in human cells in the laboratory--and does so by a previously unreported mechanism.
Credit: iStockphoto/Robert Kirk

A new UC Davis study shows that a common antibacterial chemical added to bath soaps can alter hormonal activity in rats and in human cells in the laboratory--and does so by a previously unreported mechanism.

Related Articles


The findings come as an increasing number of studies -- of both lab animals and humans -- are revealing that some synthetic chemicals in household products can cause health problems by interfering with normal hormone action.

Called endocrine disruptors, or endocrine disrupting substances (EDS), such chemicals have been linked in animal studies to a variety of problems, including cancer, reproductive failure and developmental anomalies.

This is the first endocrine study to investigate the hormone effects of the antibacterial compound triclocarban (also known as TCC or 3,4,4'-trichlorocarbanilide), which is widely used in household and personal care products including bar soaps, body washes, cleansing lotions, wipes and detergents. Triclocarban-containing products have been marketed broadly in the United States and Europe for more than 45 years; an estimated 1 million pounds of triclocarban are imported annually for the U.S. market.

The researchers found two key effects: In human cells in the laboratory, triclocarban increased gene expression that is normally regulated by testosterone. And when male rats were fed triclocarban, testosterone-dependent organs such as the prostate gland grew abnormally large.

Also, the authors said their discovery that triclocarban increased hormone effects was new. All previous studies of endocrine disruptors had found that they generally act by blocking or decreasing hormone effects.

"This finding may eventually lead to an explanation for some rises in some previously described reproductive problems that have been difficult to understand," said one author, Bill Lasley, a UC Davis expert on reproductive toxicology and professor emeritus of veterinary medicine. More analyses of antibacterials and endocrine effects are planned, he said.

Consumers should not take this study as guidance on whether to use triclocarban-containing products, Lasley said. "Our mothers taught us to wash our hands well before the advent of antimicrobial soaps, and that practice alone prevents the spread of disease."

The new study was published online during the first week in December by the journal Endocrinology ("Triclocarban enhances testosterone action: A new type of endocrine disruptor?"). The nine authors are Lasley; Jiangang Chen; Ki Chang Ahn; Nancy Gee, Mohamed I. Mohamed, Antoni Duleba, Ling Zhao, Shirley Gee and Bruce Hammock. They are associated with these UC Davis programs: Center for Health and the Environment; Department of Entomology; California National Primate Research Center; Division of Reproductive Endocrinology and Infertility at the School of Medicine; Department of Nutrition; and the Cancer Center.

The authors report that six of them have taken steps to patent their findings through the University of California.

This research was supported by the Superfund Basic Research Program of the National Institute of Environmental Health Sciences.


Story Source:

The above story is based on materials provided by University of California - Davis. Note: Materials may be edited for content and length.


Cite This Page:

University of California - Davis. "Antibacterial Chemical Disrupts Hormone Activities, Study Finds." ScienceDaily. ScienceDaily, 8 December 2007. <www.sciencedaily.com/releases/2007/12/071207150713.htm>.
University of California - Davis. (2007, December 8). Antibacterial Chemical Disrupts Hormone Activities, Study Finds. ScienceDaily. Retrieved January 30, 2015 from www.sciencedaily.com/releases/2007/12/071207150713.htm
University of California - Davis. "Antibacterial Chemical Disrupts Hormone Activities, Study Finds." ScienceDaily. www.sciencedaily.com/releases/2007/12/071207150713.htm (accessed January 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, January 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
Oxfam Calls for Massive Aid for Ebola-Hit West Africa

Oxfam Calls for Massive Aid for Ebola-Hit West Africa

AFP (Jan. 29, 2015) Oxfam International has called for a multi-million dollar post-Ebola "Marshall Plan", with financial support given by wealthy countries, to help Guinea, Sierra Leone and Liberia to recover. Duration: 01:10 Video provided by AFP
Powered by NewsLook.com
Are We Winning The Fight Against Ebola?

Are We Winning The Fight Against Ebola?

Newsy (Jan. 29, 2015) The World Health Organization announced the fight against Ebola has entered its second phase as the number of cases per week has steadily dropped. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins