Featured Research

from universities, journals, and other organizations

PET/CT Imaging Proves Golden For Detecting Cancer In Children

Date:
December 17, 2007
Source:
Society of Nuclear Medicine
Summary:
PET/CT imaging exhibits significantly higher sensitivity, specificity and accuracy than conventional imaging when it comes to detecting malignant tumors in children, according to new research. And that's not all: PET/CT imaging provides doctors with additional information about cancer in children, possibly sparing young patients from being overtreated.

PET/CT imaging exhibits significantly higher sensitivity, specificity and accuracy than conventional imaging when it comes to detecting malignant tumors in children, according to research published in the December issue of the Journal of Nuclear Medicine. And that's not all: PET/CT imaging provides doctors with additional information about cancer in children, possibly sparing young patients from being overtreated.

"PET/CT is useful in finding small tumors in small children and is a promising imaging tool in evaluating pediatric malignancies," said Richard L. Wahl, the Henry N. Wagner, Jr., M.D., Professor in Nuclear Medicine at Johns Hopkins Medical Institutions in Baltimore, Md. "In our study, we found that PET/CT can detect small lymph node lesions diagnosed as negative with conventional (or anatomical) imaging and deny the presence of active disease in soft-tissue masses post-treatment—especially in children with a wide range of malignant cancers," explained the Hopkins professor of radiology and oncology. "Using PET/CT could help spare children from overtreatment while fighting their disease," he added.

There are few findings about the use of PET/CT imaging in comparison with conventional imaging with pediatric patients, said Wahl, explaining that investigators retrospectively reviewed cases to evaluate the efficacy of PET/CT when compared with other imaging methods. Researchers reviewed 151 FDG PET/CT exams that were performed on 55 children with non–central nervous system malignancies (30 patients had lymphoma—cancer that affects the body's lymph nodes and other organs that are part of the body's immune and blood-forming systems).

PET (positron emission tomography) with CT (computed tomography) imaging—with the radiotracer fluorodeoxyglucose (FDG)—enables the collection of both biological and anatomical information during a single exam, with PET picking up metabolic signals of body cells and tissues and CT offering a detailed map of internal anatomy. "PET/CT showed its broad applicability and utility by providing additional information—in more than one third of the children's exams—that could be used by doctors to more appropriately manage or treat the disease in children," added the director of nuclear medicine/PET and vice chair of new technology and business development in the Russell H. Morgan Department of Radiology and Radiological Science. When there were discrepancies between PET/CT and conventional anatomical imaging in analyzing cancer lesions, PET/CT was diagnostically accurate 90 percent of the time, added Wahl, who pioneered the use of PET with FDG and fusion imaging in a wide range of common adult cancers.

Doctors monitor the radiation dose given to children in imaging exams, generally using lower doses than that of adult patients, to get adequate exam results, said Wahl. "Especially as a follow-up examination, PET/CT appears to be the best imaging modality currently, as it provides both PET and CT information simultaneously in pediatric patients, in whom fewer examinations are preferable," he added. Wahl indicated that additional studies with specific childhood cancers are warranted.

PET is a powerful molecular imaging procedure that noninvasively demonstrates the function of organs and other tissues. When PET is used to image cancer, a radiopharmaceutical (such as FDG, which includes both a sugar and a radionuclide) is injected into a patient. Cancer cells metabolize sugar at higher rates than normal cells, and the radiopharmaceutical is drawn in higher amounts to cancerous areas. PET scans show where FDG is by tracking the gamma rays given off by the radionuclide tagging the drug and producing three-dimensional images of their distribution within the body. PET/CT offers precise fusion of metabolic PET images with high-quality anatomical CT images.

Besides Wahl, co-authors of "18F-FDG PET/CT in Evaluating Non-CNS Pediatric Malignancies" include Mitsuaki Tatsumi, nuclear medicine division, radiology department, and John H. Miller, pediatric radiology, radiology department, all from the Johns Hopkins Medical Institutions, Baltimore, Md.


Story Source:

The above story is based on materials provided by Society of Nuclear Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Society of Nuclear Medicine. "PET/CT Imaging Proves Golden For Detecting Cancer In Children." ScienceDaily. ScienceDaily, 17 December 2007. <www.sciencedaily.com/releases/2007/12/071212201321.htm>.
Society of Nuclear Medicine. (2007, December 17). PET/CT Imaging Proves Golden For Detecting Cancer In Children. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2007/12/071212201321.htm
Society of Nuclear Medicine. "PET/CT Imaging Proves Golden For Detecting Cancer In Children." ScienceDaily. www.sciencedaily.com/releases/2007/12/071212201321.htm (accessed April 20, 2014).

Share This



More Matter & Energy News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Why Did Nike Fire Most Of Its Nike FuelBand Team?

Why Did Nike Fire Most Of Its Nike FuelBand Team?

Newsy (Apr. 19, 2014) Nike fired most of its Digital Sport hardware team, the group behind Nike's FuelBand device. Could Apple or an overcrowded market be behind layoffs? Video provided by Newsy
Powered by NewsLook.com
Small Reactors Could Be Future of Nuclear Energy

Small Reactors Could Be Future of Nuclear Energy

AP (Apr. 17, 2014) After the Fukushima nuclear disaster, the industry fell under intense scrutiny. Now, small underground nuclear power plants are being considered as the possible future of the nuclear energy. (April 17) Video provided by AP
Powered by NewsLook.com
Horseless Carriage Introduced at NY Auto Show

Horseless Carriage Introduced at NY Auto Show

AP (Apr. 17, 2014) An electric car that proponents hope will replace horse-drawn carriages in New York City has also been revealed at the auto show. (Apr. 17) Video provided by AP
Powered by NewsLook.com
Honda's New ASIMO Robot, More Human-Like Than Ever

Honda's New ASIMO Robot, More Human-Like Than Ever

AFP (Apr. 17, 2014) It walks and runs, even up and down stairs. It can open a bottle and serve a drink, and politely tries to shake hands with a stranger. Meet the latest ASIMO, Honda's humanoid robot. Duration: 00:54 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins