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Treatment With SN Reduces Injury To The Brain Following Stroke, Study Suggests

Date:
December 18, 2007
Source:
Journal of Clinical Investigation
Summary:
Stroke is the term used to describe deteriorating brain function due to either the leaking of blood vessels (hemorrhage) or oxygen deprivation (ischemia) in the brain. A new report has revealed a beneficial effect of the protein secretoneurin in rat with ischemia-induced stroke, leading the authors of the study to suggest that SN holds promise as a small-molecule drug for the treatment of individuals who have had a stroke.

Stroke is the term used to describe deteriorating brain function due to either the leaking of blood vessels (hemorrhage) or oxygen deprivation (ischemia) in the brain.

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Secretoneurin (SN) is a neural protein with various roles in the normal functioning of the brain and nervous system.

For example, SN increases blood vessel formation in mouse corneas, and its production is increased following transient brain ischemia in gerbils. In a new study, a team of researchers from the Academia Sinica, Republic of China, and the China Medical University, Republic of China, have revealed a neuroprotective role for SN in a rat model of stroke.

SN production by rats was found to be increased in neuronal and endothelial brain cells following the induction of ischemia in the brain. In vitro, SN treatment improved the survival of primary brain cell cultures subjected to oxygen/glucose deprivation.

Cell rescue was dependent on SN-induced expression of proteins that prevent a form of cell death called apoptosis.

Furthermore, when rats with ischemia-induced stroke were injected with SN, they exhibited reduced cerebral tissue death, improved motor performance, and enhanced brain function. In addition, stem cell targeting to the brain and subsequent blood vessel formation were also incited by SN injection in these animals.

From these results, the authors suggest that SN holds promise as a powerful small-molecule drug in the treatment of stroke.

Article title: Secretoneurin promotes neuroprotection and neuronal plasticity via the Jak2/Stat3 pathway in murine models of stroke


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The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Treatment With SN Reduces Injury To The Brain Following Stroke, Study Suggests." ScienceDaily. ScienceDaily, 18 December 2007. <www.sciencedaily.com/releases/2007/12/071213194124.htm>.
Journal of Clinical Investigation. (2007, December 18). Treatment With SN Reduces Injury To The Brain Following Stroke, Study Suggests. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2007/12/071213194124.htm
Journal of Clinical Investigation. "Treatment With SN Reduces Injury To The Brain Following Stroke, Study Suggests." ScienceDaily. www.sciencedaily.com/releases/2007/12/071213194124.htm (accessed March 30, 2015).

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