Featured Research

from universities, journals, and other organizations

Breast Cancer Gene Mutation More Common In Hispanic, Young Black Women, Study Finds

Date:
December 27, 2007
Source:
Stanford University Medical Center
Summary:
A genetic mutation already known to be more common in Ashkenazi Jewish breast cancer patients is also prevalent in Hispanic and young African-American women with breast cancer, according to one of the largest, multiracial studies of the mutation to date.

A genetic mutation already known to be more common in Ashkenazi Jewish breast cancer patients is also prevalent in Hispanic and young African-American women with breast cancer, according to one of the largest, multiracial studies of the mutation to date.

Related Articles


Researchers at the Stanford University School of Medicine and the Northern California Cancer Center reported the finding from a study of 3,181 breast cancer patients in Northern California. It revealed that although Ashkenazi Jewish women with breast cancer had the highest rate of the BRCA1 mutation at 8.3 percent, Hispanic women with breast cancer were next most likely, with a rate of 3.5 percent. Non-Hispanic whites with breast cancer showed a 2.2 percent rate, followed by 1.3 percent of African-American women of all ages and 0.5 percent in Asian-American women. Of the African-American breast cancer patients under age 35, 16.7 percent had the mutation.

The work, which will be published in the Dec. 26 issue of the Journal of the American Medical Association, marks the largest study to date to look at the prevalence of BRCA1 mutations among patients in the four ethnic and racial groups, said lead author Esther John, PhD, research scientist at the Northern California Cancer Center and consulting associate professor of health research and policy at Stanford.

The information could help doctors decide which patients to refer to genetic counseling, the researchers said. They added that they hope the information prompts genetic counselors to develop materials for discussing breast cancer risk in a culturally sensitive way and in languages other than English.

"If a woman has breast cancer she may ask the question, 'Could I be a carrier for a BRCA1 mutation" If I am, my daughters and sons need to know it,'" said senior author Alice Whittemore, PhD, professor of health research and policy at Stanford. She said that until now, doctors knew only that Ashkenazi Jewish women were more likely to carry a mutation, and therefore frequently referred these women to genetic counseling. What they didn't know is how women of different ethnic groups needed to be treated in terms of their BRCA1 status.

"Traditionally studies have focused on white women," said John. "There is a great need to study racial minorities in the United States."

The risk of a woman developing breast cancer sometime during her life is about one in eight. Although death rates from the disease are dropping, the American Cancer Society estimates that 40,000 women will die from the disease this year.

All people have the BRCA1 gene, which makes a protein that helps the cell repair its DNA. Women who inherit a mutation in that gene from either parent are less able to fix DNA damage and tend to accumulate mutations that lead to cancer. They have a roughly 65 percent risk of developing breast cancer and 39 percent risk of ovarian cancer. If one family member tests positive for a mutation, it can alert other women in the family to also get tested and to take preventive measures.

Without the information from this study, doctors have treated all women other than Ashkenazi Jews as having the same risk level for the mutation. Now doctors who see Hispanic or young African-American breast cancer patients have more information to guide their decisions about referring those women to genetic counseling or testing.

"The message is that these minority breast cancer patients may need screening in ways that we hadn't appreciated before," Whittemore said. She noted that Hispanic women in Northern California, where this study was conducted, derive from different countries than Hispanic women from the East Coast. For that reason, the findings may not apply to Hispanic people in other parts of the country.

The research team found a few other surprises in the data. One is that although mutations can occur throughout the BRCA1 gene, the Hispanic women in the study were more likely to carry a particular mutation that's also common in Ashkenazi Jewish women. Other ethnic groups carried a wide range of different mutations.

John and Whittemore think the Hispanic women may have this mutation because of their Spanish ancestry. Spain was the home of Sephardic Jews who could have shared the mutation with Ashkenazi Jews of Eastern European origin.

The prevalence of the mutation in young African-American women with breast cancer also came as a surprise, given that the rate is low in the overall African-American population. The researchers say the finding is consistent with a long-known pattern that when young African-American women get breast cancer it tends to be a particularly aggressive form of the disease, which is a hallmark of tumors that arise from BRCA1 mutations. Whittemore said this information doesn't change how doctors treat those tumors, but it could help prompt more doctors to recommend genetic counseling for those young African-American breast cancer patients.

Other Stanford researchers who participated in this study include Gail Gong, PhD, a research associate; Anna Felberg, a programmer in health research and policy; Dee West, PhD, professor of health research and policy at Stanford and chief scientific officer at the Northern California Cancer Center, and Amanda Phipps, epidemiologist at the NCCC.

The work was funded by the National Cancer Institute.


Story Source:

The above story is based on materials provided by Stanford University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Stanford University Medical Center. "Breast Cancer Gene Mutation More Common In Hispanic, Young Black Women, Study Finds." ScienceDaily. ScienceDaily, 27 December 2007. <www.sciencedaily.com/releases/2007/12/071226003653.htm>.
Stanford University Medical Center. (2007, December 27). Breast Cancer Gene Mutation More Common In Hispanic, Young Black Women, Study Finds. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2007/12/071226003653.htm
Stanford University Medical Center. "Breast Cancer Gene Mutation More Common In Hispanic, Young Black Women, Study Finds." ScienceDaily. www.sciencedaily.com/releases/2007/12/071226003653.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins