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Toward Solving The Mystery Of Idiosyncratic Drug Reactions

Date:
January 8, 2008
Source:
American Chemical Society
Summary:
A mysterious and unpredictable group of side effects from modern medications called idiosyncratic drug reactions likely will persist as a major health care problem unless there is a dramatic increase in research funding, according to a 20-year review of research in the field.
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A mysterious and unpredictable group of side effects from modern medications called idiosyncratic drug reactions (IDRs) likely will persist as a major health care problem unless there is a dramatic increase in research funding, according to a 20-year review of research in the field.

The review, by Jack Uetrecht, defines IDRs as reactions that happen unexpectedly and with no obvious connection to the known effects of a medication's ingredients or dosage. Although relatively rare, IDRs make an important contribution to the annual burden of death, illness, and increased health care costs from serious adverse drug reactions. In addition, serious IDRs that appear after a new drug has gone into wide use can force drug companies to withdraw products after R&D investments totaling hundreds of millions of dollars.

Two decades of research have produced significant progress, the report acknowledges. However, medical science still has only a "superficial" understanding of how and why IDRs occur and a growing recognition that the mechanisms behind IDRs may be as complicated as those involved in cancer or diabetes. The review describes a need for increased research funding, with more scientists focusing on IDRs, in order to achieve faster progress.

The article "Idiosyncratic Drug Reactions: Past, Present, and Future" is  scheduled for the January issue of ACS' Chemical Research in Toxicology.


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The above post is reprinted from materials provided by American Chemical Society. Note: Materials may be edited for content and length.


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American Chemical Society. "Toward Solving The Mystery Of Idiosyncratic Drug Reactions." ScienceDaily. ScienceDaily, 8 January 2008. <www.sciencedaily.com/releases/2008/01/080107104539.htm>.
American Chemical Society. (2008, January 8). Toward Solving The Mystery Of Idiosyncratic Drug Reactions. ScienceDaily. Retrieved July 3, 2015 from www.sciencedaily.com/releases/2008/01/080107104539.htm
American Chemical Society. "Toward Solving The Mystery Of Idiosyncratic Drug Reactions." ScienceDaily. www.sciencedaily.com/releases/2008/01/080107104539.htm (accessed July 3, 2015).

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