Featured Research

from universities, journals, and other organizations

FDA Warnings Affected Prescriptions Of Antidepressants To Youth

Date:
January 10, 2008
Source:
JAMA and Archives Journals
Summary:
US Food and Drug Administration warnings regarding the risk of suicidal thoughts and behaviors in children and adolescents taking antidepressants appear to have had modest and targeted effects on the intended populations, according to a new report.

U.S. Food and Drug Administration warnings regarding the risk of suicidal thoughts and behaviors in children and adolescents taking antidepressants appear to have had modest and targeted effects on the intended populations, according to a new report.

Related Articles


"The possibility that antidepressant medications, especially selective serotonin reuptake inhibitors (SSRIs), increase the risk of suicidal behavior was first raised in several case reports of children and adults during the early 1990s," the authors write as background information in the article. "In June 2003, the Food and Drug Administration (FDA) recommended that paroxetine hydrochloride not be used to treat young people because of potential increased risk of suicidal behavior, and in October 2004, the FDA issued a black box warning concerning all antidepressants for youth." This warning received extensive media attention and is the strongest action the FDA can take other than withdrawing approval for a drug.

Mark Olfson, M.D., M.P.H., of the Columbia University Medical Center, New York, and colleagues analyzed trends in antidepressant use based on data from Medco, a company that manages prescription drug benefits. The researchers assessed antidepressant prescriptions for youth (age 6 to 17), adults (age 18 to 64) and older adults (age 65 and older) over three time periods: prewarning (May 1, 2002, to June 19, 2003), paroxetine warning (June 20, 2003, to Oct. 15, 2004) and black box warning (Oct. 16, 2004, to Dec. 31, 2005).

"After the FDA first recommended not treating youth with paroxetine, there was a significant absolute decline in paroxetine use by youth but not significant declines in use of other antidepressants by young people," the authors write. "Similar, though less pronounced, declines occurred in paroxetine treatment of older patients. Following the black box warning, there was a statistically nonsignificant decline in antidepressant treatment of youth, including a significant deceleration in the rate of treatment with SSRIs other than paroxetine."

The warnings appeared to effectively increase the perception of the risks involved with antidepressant treatment, especially in young people, the authors note. "From 1985 to 1999, there was a four-fold national increase in per capita antidepressant prescriptions," they write. "The FDA warnings appear to have slowed this longer-term growth of antidepressant treatment of children and adults. Despite fears that these advisories might result in a precipitous decline in antidepressant prescribing, it is reassuring that the pattern of changes in treatment, which were modest in size and greatest for treatment of youth, were broadly consistent with the FDA warnings and the scientific literature."

Journal reference: Arch Gen Psychiatry. 2008;65(1):94-101.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Cite This Page:

JAMA and Archives Journals. "FDA Warnings Affected Prescriptions Of Antidepressants To Youth." ScienceDaily. ScienceDaily, 10 January 2008. <www.sciencedaily.com/releases/2008/01/080107181537.htm>.
JAMA and Archives Journals. (2008, January 10). FDA Warnings Affected Prescriptions Of Antidepressants To Youth. ScienceDaily. Retrieved March 5, 2015 from www.sciencedaily.com/releases/2008/01/080107181537.htm
JAMA and Archives Journals. "FDA Warnings Affected Prescriptions Of Antidepressants To Youth." ScienceDaily. www.sciencedaily.com/releases/2008/01/080107181537.htm (accessed March 5, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Thursday, March 5, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Former NFL Players Donate Brains to Science

Former NFL Players Donate Brains to Science

Reuters - US Online Video (Mar. 3, 2015) Super Bowl champions Sidney Rice and Steve Weatherford donate their brains, post-mortem, to scientific research into repetitive brain trauma. Jillian Kitchener reports. Video provided by Reuters
Powered by NewsLook.com
Alzheimer's Protein Plaque Found In 20-Year-Olds

Alzheimer's Protein Plaque Found In 20-Year-Olds

Newsy (Mar. 3, 2015) Researchers found an abnormal protein associated with Alzheimer&apos;s disease in the brains of 20-year-olds. Video provided by Newsy
Powered by NewsLook.com
This Nasal Treatment Could Help Ease Migraine Pain

This Nasal Treatment Could Help Ease Migraine Pain

Newsy (Mar. 2, 2015) Researchers gave lidocaine to 112 patients, and about 88 percent of the subjects said they needed less migraine-relief medicine the next day. Video provided by Newsy
Powered by NewsLook.com
How Facebook Use Can Lead To Depression

How Facebook Use Can Lead To Depression

Newsy (Mar. 1, 2015) Margaret Duffy of the University of Missouri talks about her study on the social network and the envy and depression that Facebook use can cause. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins