Featured Research

from universities, journals, and other organizations

Monkey Malaria Widespread In Humans And Potentially Fatal

Date:
January 17, 2008
Source:
Wellcome Trust
Summary:
A potentially fatal species of malaria is being commonly misdiagnosed as a more benign form of the disease, thereby putting lives at risk, according to new research. Malaria, which kills more than one million people each year, is caused when Plasmodium parasites are passed into the bloodstream from the salivary glands of mosquitoes.

A potentially fatal species of malaria is being commonly misdiagnosed as a more benign form of the disease, thereby putting lives at risk, according to research funded by the Wellcome Trust and the University Malaysia Sarawak.

Researchers in Malaysia studied more than 1,000 samples from malaria patients across the country. Using DNA-based technology they found that more than one in four patients in Sarawak, Malaysian Borneo, were infected with Plasmodium knowlesi, a malaria parasite of macaque monkeys, and that the disease was more widespread in Malaysia than previously thought. Infections were most often misdiagnosed as the normally uncomplicated human malaria caused by P. malariae.

Malaria, which kills more than one million people each year, is caused when Plasmodium parasites are passed into the bloodstream from the salivary glands of mosquitoes. Some types, such as P. falciparum, found most commonly in Africa, are more deadly than others. P. malariae, found in tropical and sub-tropical regions across the globe, is often known as "benign malaria" as its symptoms are usually less serious than other types of malaria.

Until recently, P. knowlesi, was thought to infect only monkeys, in particular long-tailed macaques found in the rainforests of South East Asia. Natural infections of man were thought to be rare until human infections were described in one area in Sarawak, Malaysian Borneo. However, in a study published today in the journal Clinical Infectious Diseases, Professors Janet Cox-Singh and Balbir Singh with colleagues at the University Malaysia Sarawak and three State Departments of Health in Malaysia have shown that knowlesi malaria is widespread in Malaysia.

Under the microscope, the early parasite stages of P. knowlesi look very similar to P. falciparum, the most severe form of human malaria, while the later parasite stages are indistinguishable from the more benign P. malariae. Misdiagnosis as P. falciparum is clinically less important as P. falciparum infections are treated with a degree of urgency and P. knowlesi responds to the same treatment. However, misdiagnosis as the more benign slower growing parasite P. malariae is a problem.

P. knowlesi is unprecedented among the malaria parasites of humans and non-human primates as it reproduces every 24 hours, and one of the features of fatal P. knowlesi infections is the high number of infected red blood cells in these patients. Therefore, even a short delay in accurate diagnosis and treatment could lead to the rapid onset of complications, including liver and kidney failure, and death.

Using DNA detection methods, Professor Cox-Singh and colleagues found malaria infection with P. knowlesi to be widely distributed in Malaysian Borneo and mainland Malaysia, sometimes proving fatal. In addition, single human infections have been reported in Thailand and Myanmar.

"I believe that if we look at malaria infections in South East Asia more carefully, we will find that this potentially fatal type of the disease is more widespread than is currently thought," says Professor Cox-Singh. "Given the evident severity of the illness that it causes, I would recommend that doctors treating patients with a laboratory diagnosis of P. malariae remain alert to the possibility that they may be dealing with the potentially more aggressive P. knowlesi. This would be particularly important in patients who have spent time in the forest fringe areas of South East Asia where the non-human primate host exists."


Story Source:

The above story is based on materials provided by Wellcome Trust. Note: Materials may be edited for content and length.


Cite This Page:

Wellcome Trust. "Monkey Malaria Widespread In Humans And Potentially Fatal." ScienceDaily. ScienceDaily, 17 January 2008. <www.sciencedaily.com/releases/2008/01/080115132850.htm>.
Wellcome Trust. (2008, January 17). Monkey Malaria Widespread In Humans And Potentially Fatal. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2008/01/080115132850.htm
Wellcome Trust. "Monkey Malaria Widespread In Humans And Potentially Fatal." ScienceDaily. www.sciencedaily.com/releases/2008/01/080115132850.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins