Featured Research

from universities, journals, and other organizations

Diet And Lifestyle Critical To Recovery, Says Study

Date:
January 20, 2008
Source:
University of Manchester
Summary:
Diet and lifestyle may play a much more significant role in a person's ability to respond favorably to certain drugs, including some cancer therapies, than previously understood, say scientists.

Diet and lifestyle may play a much more significant role in a person's ability to respond favourably to certain drugs, including some cancer therapies, than previously understood, say scientists.

Writing in Nature Genetics, University of Manchester researchers have shown how the nutrients in the environment are critical to the fitness of cells that carry genetic mutations caused by diseases.

The findings for the first time provide a scientific insight into why some people might respond better to certain medications than others and form the foundations for more individualised drug therapy in the future.

The team used baker's yeast -- a model organism studied by biologists to reveal molecular processes in higher organisms -- to explore the relationship between environment and genetic background.

The large-scale study involved removing one of the two copies of all yeast genes -- similar to removing one parent's set of genes in a human -- and analysing the resulting fitness under different dietary restrictions. "If the gene targeted is quantitatively important, you would normally expect the yeast to show a reduction in fitness," said Dr Daniela Delneri, who carried out the research in the University's Faculty of Life Sciences.

"But what we found was that in certain environmental conditions, removing one copy of certain genes actually produced the opposite effect and surprisingly the yeast cells grew more quickly and were healthier."

The team further established that this effect was mainly occurring in genes involved in the proteasome -- the quality-control system within the cell that degrades unwanted proteins. "The proteasome is important as it maintains the equilibrium of the cell," said Dr Delneri. "When this equilibrium is lost it can result in a number of diseases, including cancer, diabetes, Huntingdon's, Alzheimer's and Parkinson's.

"For example, in rapidly-growing cancerous cells the high proteasome activity renders the tumour cells immortal, so drugs that block or inhibit the proteasome's actions are currently used as therapeutic compounds.

"Our study shows that reduced proteasome activity could be either advantageous or damaging to the cell depending on the nutrients available to it in the surrounding environment."

The findings suggest that, ideally, when therapeutic drugs are administered to alter the proteasome activity, the environment -- governed by the type of tissue or a person's diet and lifestyle -- should be taken into consideration to assure the correct beneficial effect.


Story Source:

The above story is based on materials provided by University of Manchester. Note: Materials may be edited for content and length.


Cite This Page:

University of Manchester. "Diet And Lifestyle Critical To Recovery, Says Study." ScienceDaily. ScienceDaily, 20 January 2008. <www.sciencedaily.com/releases/2008/01/080117093423.htm>.
University of Manchester. (2008, January 20). Diet And Lifestyle Critical To Recovery, Says Study. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2008/01/080117093423.htm
University of Manchester. "Diet And Lifestyle Critical To Recovery, Says Study." ScienceDaily. www.sciencedaily.com/releases/2008/01/080117093423.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins